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IgA nephropathy diagnostic kit and application

A technology of kits and reagents, applied in biochemical equipment and methods, microbial measurement/testing, etc., can solve the problems that cannot fully explain the occurrence and development of IgAN, and have not fully elucidated the pathogenesis of IgAN

Inactive Publication Date: 2019-01-11
SHENZHEN PEOPLES HOSPITAL
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

However, the above studies are mainly related to DNA and mRNA, which have not completely clarified the pathogenesis of IgAN, and cannot fully explain the occurrence and development of IgAN. Therefore, it is necessary to explain the pathogenesis of IgAN from a new perspective

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  • IgA nephropathy diagnostic kit and application
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Embodiment Construction

[0015] The conception of the present invention and the technical effects produced will be clearly and completely described below in conjunction with experiments, so as to fully understand the purpose, characteristics and effects of the present invention.

[0016] research object

[0017] The cases were from IgAN patients who were treated in Shenzhen People's Hospital. All patients were confirmed by renal biopsy. According to the "Evidence-Based Guidelines for the Diagnosis and Treatment of Primary IgA Nephropathy (2016)", the immunopathological examination and immunofluorescence characteristics were selected as glomerular system. IgA-dominated immunoglobulin deposition or only IgA deposition in the membranous area or associated capillary loops. All subjects have excluded purpura nephritis, hepatitis B-related nephritis and systemic lupus erythematosus and other diseases based on clinical data. The IgAN group included 20 patients with IgAN, and the normal healthy control gro...

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Abstract

The invention provides an IgAN diagnostic kit and an application thereof. The IgAN diagnostic kit takes the tRNA is taken as the cut-in point for the first time, studies the tRNA expression profiles of IgAN patients, and screens out the differentially down-regulated tRNA of IgAN patients, which can be used as one of the important means of IgAN diagnosis and prognosis, in order to diagnose the disease more conveniently and accurately, so as to lay a foundation for the treatment of the disease in the future.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a diagnostic kit for IgA nephropathy and its application. Background technique [0002] IgA nephropathy (IgA nephrology, IgAN) is a primary glomerular disease with IgA deposition in the glomerular mesangial area or mainly deposition. It is one of the common primary glomerular diseases, and it is also the most common glomerular disease in my country. Existing studies have shown that IgAN is a complex disease determined by multiple genes and factors. The diagnosis of IgAN depends on the pathology of renal biopsy, and its manifestations are diverse, mainly mesangial proliferative glomerulonephritis, with varying severity. The clinical manifestations of IgAN are diverse, covering almost all clinical features of glomerulonephritis. Gross hematuria may induce acute renal failure in IgAN, in which up to 25% of patients fail to return to baseline renal function. Proteinuria patients older...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6883
CPCC12Q1/6883C12Q2600/118C12Q2600/158
Inventor 戴勇徐慧璇汤冬娥徐勇陈文标郑凤屏
Owner SHENZHEN PEOPLES HOSPITAL