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Glioblastoma auxiliary diagnosis and prognosis evaluation kit based on ITGB5 gene and use method thereof

A glioblastoma, auxiliary diagnosis technology, applied in the field of biomedicine, to achieve the effect of objective evaluation and reduction of survival time

Active Publication Date: 2019-01-11
THE FIRST HOSPITAL OF CHINA MEDICIAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there is no report on the kit for ITGB5 gene in glioma

Method used

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  • Glioblastoma auxiliary diagnosis and prognosis evaluation kit based on ITGB5 gene and use method thereof
  • Glioblastoma auxiliary diagnosis and prognosis evaluation kit based on ITGB5 gene and use method thereof
  • Glioblastoma auxiliary diagnosis and prognosis evaluation kit based on ITGB5 gene and use method thereof

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Embodiment Construction

[0033] The present invention will be further described in detail below through specific embodiments and accompanying drawings. The following examples only further illustrate the present invention, and should not be construed as limiting the present invention. The experimental methods in the following examples are conventional methods unless otherwise specified, and the involved experimental reagents and materials are conventional biochemical reagents and materials unless otherwise specified.

[0034] Example.

[0035] 1. The ITGB5 gene is significantly different in the database, which is a sign of malignant progression of glioma.

[0036] This study mainly includes two database platforms, Chinese Glioma Genome Atlas (CGGA) and The Cancer Genome Atlas (TCGA). CGGA is a database for the analysis of Chinese glioma patient samples initiated and established by Beijing Tiantan Hospital in 2012. It is a large-scale database unique to my country that can reveal the molecular mechani...

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Abstract

The invention relates to the field of biomedical specialty, in particular to a glioblastoma auxiliary diagnosis and prognosis evaluation kit based on ITGB5 gene and a use method thereof. The present invention describes the functional role of ITGB5 gene in glioma and prepares a kit for evaluating the adverse prognosis and the effect of radiotherapy and chemotherapy.

Description

technical field [0001] The invention belongs to the professional field of biomedicine, and in particular relates to an ITGB5 gene-based kit for auxiliary diagnosis and prognosis evaluation of glioblastoma and a use method thereof. Background technique [0002] Glioblastoma (GBM) is the most common primary malignancy in the adult central nervous system (CNS). Even with maximal surgical resection, radiotherapy, and adjuvant temozolomide chemotherapy, the median survival of GBM patients is only 12–15 months, and only about 10% of GBM patients survive beyond 5 years. In recent years, more and more studies targeting the tumor immune microenvironment have emerged, and immunotherapy has emerged as a new strategy for solid tumors and has revolutionized treatment in some specific types of cancer. For example, immune checkpoint inhibitors such as nivolumab and ipilimumab have enabled long-term survival in a subset of patients with advanced melanoma that was previously incurable, with...

Claims

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Application Information

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IPC IPC(8): C12Q1/6886C12Q1/6851
CPCC12Q1/6851C12Q1/6886C12Q2600/118C12Q2600/166C12Q2531/113C12Q2563/107
Inventor 吴安华程鹏郭清管格非曹靖元
Owner THE FIRST HOSPITAL OF CHINA MEDICIAL UNIV