Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Ligustrum lucidum glycoside concentrate and application thereof

A technology for glycosides and concentrates of Ligustrum lucidum, which is applied in the field of medical applications of the aforementioned glycoside concentrates of Ligustrum lucidum, and can solve problems such as complex prescriptions of traditional Chinese medicine compositions

Active Publication Date: 2019-01-29
LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE
View PDF3 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent CN104800564A discloses a complex prescription of traditional Chinese medicine composition

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Ligustrum lucidum glycoside concentrate and application thereof
  • Ligustrum lucidum glycoside concentrate and application thereof
  • Ligustrum lucidum glycoside concentrate and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1--the preparation method of Ligustrum lucidum glucoside enrichment

[0022] like figure 1 As shown, 3kg of Ligustrum lucidum plus 12 times the volume concentration of 70% ethanol, reflux extraction for 1.5h, filtered, plus 8 times the volume concentration of 70% ethanol for the dregs, reflux extraction for 1.5h, filtered, Combine the two filtrates, recover the solvent to 3L, add ethyl acetate to extract twice, 3L each time, discard the ethyl acetate layer, add water-saturated n-butanol to extract 3 times, each time 3L, combine the water-saturated n-butanol layer , concentrated, and vacuum-dried to obtain the glucoside enrichment of Ligustrum lucidum, which is used for subsequent test examples.

Embodiment 2

[0023] Embodiment 2--other preparations of Ligustrum lucidum glycoside enrichment

[0024] The values ​​of the three factors of ethanol concentration, volume, and reflux time in Example 1 were adjusted and combined (as shown in Table 1 below), and other preparation methods were kept unchanged to obtain Ligustrum lucidum glycoside enrichment A-H.

[0025] Table 1

[0026]

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a ligustrum lucidum glucoside concentrate and an application thereof. A preparation method of the ligustrum lucidum glucoside concentrate has the following steps: adding 10-14times amount of ethanol having a volume concentration of 50-80% into ligustrum lucidum, performing reflux extraction for 1-3 h, filtering, adding 8 times amount of the ethanol having a volume concentration of 50-80% into medicine residues, performing reflux extraction for 1-3 h, filtering, combining two filtrates, recovering solvents, adding appropriate amount of ethyl acetate for extraction, discharging an ethyl acetate layer, adding water-saturated n-butanol into a water layer for extraction, combining a water-saturated n-butanol layer, condensing, and performing vacuum drying to prepare theligustrum lucidum glucoside concentrate. The invention also discloses an application of the ligustrum lucidum glucoside concentrate in preparation of medicine for treating hypoparathyroidism.

Description

technical field [0001] The present invention relates to a glycoside-enriched product of Ligustrum lucidum, and furthermore, the invention also relates to the medical application of the above-mentioned glycoside-enriched product of Ligustrum lucidum. Background technique [0002] Hypoparathyroidism (hypoparathyroidism) is abnormal calcium and phosphorus metabolism caused by decreased secretion and / or dysfunction of parathyroid hormone (PTH). Once it occurs, it will seriously affect the quality of life of patients. Parathyroid injury or missection caused by neck surgery is the most common cause of secondary hypoparathyroidism. The larger the extent of thyroidectomy, the higher the incidence of hypoparathyroidism. When parathyroid hypocalcemia occurs, neuromuscular excitability increases, muscle spasms, tetany and convulsions may occur, and severe cases are life-threatening; bone calcium deficiency is manifested as osteomalacia and loosening; the membrane barrier effect on ion...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/638A61P5/18
CPCA61K36/638A61K2236/333A61K2236/39A61K2236/51A61K2236/53
Inventor 张岩王拥军李强刘书芬
Owner LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com