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Application of Babaodan in preparing medicine for preventing and treating acute liver failure

A technology of acute liver failure, Babaodan, which is applied in the field of preparing and preventing acute liver failure, Babaodan, which can solve the problems of undiscovered literature reports in the field of liver disease, achieve good development prospects, and reduce the degree of liver damage , Improve the effect of liver function

Inactive Publication Date: 2019-02-05
SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And it has been verified that there is no patent related to the content of this application, and no literature reports have been found on the application of traditional Chinese medicine prescriptions in the field of liver diseases that are identical to the patents of this application.

Method used

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  • Application of Babaodan in preparing medicine for preventing and treating acute liver failure
  • Application of Babaodan in preparing medicine for preventing and treating acute liver failure
  • Application of Babaodan in preparing medicine for preventing and treating acute liver failure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1 8

[0025] Example 1 Babaodan can significantly prevent and treat TAA-induced acute liver failure model in rats

[0026] 1. Materials and methods

[0027] 1.1 Animals

[0028] 40 Wistar male rats, SPF grade, body weight (200±20) g, were provided by the Experimental Animal Center of Shanghai University of Traditional Chinese Medicine. Animal license number: SYXK (Shanghai 2014-008). The animals were raised, modeled and observed in the animal center, with free access to food and water.

[0029] 1.2 Drugs and reagents

[0030] TAA (China Pharmaceutical Group Shanghai Chemical Reagent Company, product batch number: 20160930), Babaodan (produced by Xiamen Traditional Chinese Medicine Factory Co., Ltd., product batch number: 160603), serum TBil, ALT, AST, total bile acid (TBA), total protein (TP) and Alb detection kits were purchased from Nanjing Jiancheng Institute of Bioengineering.

[0031] 1.3 Model preparation

[0032] [Terblanche J, Hickman R. Animal models of fulminanthepat...

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Abstract

The invention relates to the technical field of new indication of a medicine, and specifically relates to an application of Babaodan in preparing a medicine for preventing and treating acute liver failure. The application of Babaodan in preparing a medicine for acute liver failure designed in the invention is revealed for the first time; the traditional Chinese medicine Babaodan provided by the invention is verified repeatedly by thioacetamide (TAA) induced acute liver failure rat model experiments, and the result proves that the Babaodan can remarkably improve the liver function and relieve the degrees of liver necrosis and liver injury. Therefore, the Babaodan can be used for preparing a medicine for preventing and treating acute liver failure, and has a good prospect in development andapplication.

Description

technical field [0001] The invention relates to the technical field of new indications of medicines, in particular to the use of Babaodan in the preparation of medicines for preventing and treating acute liver failure. Background technique [0002] Acute liver failure (ALF) is a clinical syndrome characterized by liver failure as the main manifestation accompanied by severe complications of other multiple organs. The mortality rate is extremely high. Jaundice and hepatic encephalopathy (HE) will appear within 2 weeks , accompanied by coagulation dysfunction [PTA ≤ 40% or International Normalized Ratio (INR) ≥ 1.5], severe liver necrosis and systemic reactions of the body. Clinical treatment of acute liver failure mostly adopts comprehensive medical treatment such as eliminating the etiology, improving immune function and preventing complications, but the curative effect is not satisfactory. At present, there are few researches on drugs for the prevention and treatment of ac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61P1/16A61K35/413A61K35/583A61K35/32A61K35/618A61K35/55
CPCA61K35/32A61K35/413A61K35/55A61K35/583A61K35/618A61K36/258A61P1/16A61K2300/00
Inventor 孙明瑜陆璐鲁冰洁武超叶冠谢咚陈曦孙润菲
Owner SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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