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Nicotine particles

A nicotine and granule technology, applied in the fields of drug combination, disinfection, nervous system diseases, etc., can solve the problems of handling and storage of nicotine granule composition, and achieve the effect of enhancing the inhalation experience

Active Publication Date: 2019-02-05
PHILIP MORRIS PROD SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This can cause handling and storage issues with nicotine granule compositions

Method used

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  • Nicotine particles
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Examples

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[0065] All examples (except the examples in Table 3) were formulated by mixing nicotine base and acid in water (in the proportions specified) to form a stable nicotine salt solution. The sugar and amino acid (leucine) are then combined with the nicotine salt solution to form a liquid mixture. The liquid mixture is then atomized and dried to form dry particles collected from the dry powder composition.

[0066] The examples of Table 3 were formulated by combining nicotine free base with sugar and amino acid (leucine) to form a liquid mixture. The liquid mixture is then atomized and dried to form dry particles collected from the dry powder composition.

[0067] The spray dryer was a Buchi B-290 spray dryer (commercially available from Buchi Corp., DE, USA). The liquid mixture was supplied to the spray dryer at a flow rate of 2 ml / min at an atomization pressure of 5 bar. For the example utilizing trehalose, the outlet temperature was about 80 degrees Celsius. Table 1 below de...

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Abstract

A method includes combining nicotine with a liquid carrier to form a liquid mixture and spray drying the liquid mixture to form a first plurality of particles. The first pluralities of particles are then milled to form a second plurality of particles.

Description

technical field [0001] The present disclosure relates to nicotine particles suitable for inhalation. The nicotine granules are formed by spray drying before being milled. Background technique [0002] Dry powder inhalers (DPIs) are known and used for the treatment of respiratory diseases by delivering a dry powder comprising a pharmaceutically active compound in aerosol form to the respiratory tract of a patient by inhalation. In pharmaceutical dry powders, the active pharmaceutical ingredient (API) is usually agglomerated on the surface of larger carrier particles such as lactose. The DPI's operating mechanism is complex to ensure that such agglomerates are dispersed, lysed or disaggregated before the API is inhaled into the lungs. [0003] It may be difficult to deliver nicotine particles to the lungs when inhaled in conventional smoking patterns or at airflow rates within the range of airflow rates. Nicotine particles may have a tendency to agglomerate and stick to inh...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61L9/16
CPCA61K9/1623A61K9/1682A61K31/465A61K9/0075A61P25/34A61K9/1617
Inventor N·沃尔普
Owner PHILIP MORRIS PROD SA
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