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Preparation of platelet pellet lysate and its use for treating neurological disorders

A neurological disease, lysate technology, applied in the field of obtaining a new type of platelet precipitation lysate, to achieve the effect of enhancing neuroprotective activity

Active Publication Date: 2019-02-05
里尔大学中心医院 +4
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This may be the reason why platelet lysates have not been reported in the field of neurodegenerative diseases such as Parkinson's disease in humans

Method used

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  • Preparation of platelet pellet lysate and its use for treating neurological disorders
  • Preparation of platelet pellet lysate and its use for treating neurological disorders
  • Preparation of platelet pellet lysate and its use for treating neurological disorders

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Experimental program
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Embodiment Construction

[0096] The following abbreviations are used throughout the specification, drawings and claims:

[0097] BAFF: B cell activating factor;

[0098] BDNF: brain-derived neurotrophic factor;

[0099] C5 / C5a: complement component 5 / activation;

[0100] CSF: cerebrospinal fluid;

[0101] Ctrl: control;

[0102] Dkk-1: Dickkopf WNT signaling pathway inhibitor 1;

[0103] DPPIV: dipeptidyl peptidase IV;

[0104] EGF: epithelial growth factor;

[0105] EMMPRIN: extracellular matrix metalloproteinase inducer;

[0106] ENA-78: epithelial-derived neutrophil-activating peptide 78;

[0107] FGF: fibroblast growth factor;

[0108] FGF-β: Fibroblast Growth Factor-β;

[0109] Fas L: fas ligand;

[0110] G-CSF: granulocyte colony-stimulating factor;

[0111] GDF-15: growth differentiation factor 15;

[0112] HGF: hepatocyte growth factor;

[0113] IGFBP-2: insulin-like growth factor binding protein-2;

[0114] IL: interleukin;

[0115] IP-10: interferon protein 10;

[0116] I-TAC...

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Abstract

A process for preparing a modified heat-treated platelet pellet lysate, said process comprising the steps of: a) Providing a platelet pellet lysate, b) Heat-treating the platelet pellet lysate at a temperature of 55 DEG C to 65 DEG C during 20 to 40 minutes, c) Purifying the heat-treated platelet pellet lysate of step b) so as to obtain a modified heat treated platelet pellet lysate having a totalprotein content of less than 70% of the total protein content of the platelet pellet lysate of step a).

Description

technical field [0001] The present invention relates to methods for obtaining novel platelet precipitate lysates, platelet precipitates themselves and their use in the treatment of neurological disorders such as neurodegenerative, neuroinflammatory, neurodevelopmental and / or neurovascular disorders (i.e. stroke), as well as brain injury (traumatic brain injury) injury, hypoxia...) consequences of use. Background technique [0002] Given the enormous social and economic impact of these diseases on patients and caregivers, there is an urgent need to develop effective "disease-modifying strategies" that provide neuroprotection, neurorestoration, and neurogenesis to treat neurodegenerative diseases such as Parkinson's disease (PD ), amyotrophic lateral sclerosis (ALS), and Alzheimer's disease (AD). [0003] Given the lack of proven treatments, it is also highly desirable to develop effective treatments that provide neurorestoration and neurogenesis to compensate for the loss of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/19A61P25/00A61P25/16A61P25/28
CPCA61K35/19A61P25/28A61P25/16
Inventor D·德沃斯T·布努夫J-C·德威德疆周明礼
Owner 里尔大学中心医院