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A traditional Chinese medicine "full component" extract with health benefits, its preparation method and application

An extract and full-component technology, applied in the field of "full-component" extracts of traditional Chinese medicine, can solve problems such as large dosage, restrict compliance, and safety doubts, achieve easy absorption, enhance immunity, and relieve physical fatigue. Effect

Active Publication Date: 2021-11-16
UNIVERSITY OF MACAU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the micro-powder medicinal materials retain the integrity of the active ingredients of the medicinal materials to a certain extent and improve the dissolution and absorption of the active ingredients, the large dosage still restricts the compliance of its clinical use
In addition, the easy contamination during the storage and circulation of the raw powder of medicinal materials, and the potential irritation of the gastrointestinal mucosa by direct consumption of the powdered medicinal materials have also made their safety questionable.

Method used

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  • A traditional Chinese medicine "full component" extract with health benefits, its preparation method and application
  • A traditional Chinese medicine "full component" extract with health benefits, its preparation method and application
  • A traditional Chinese medicine "full component" extract with health benefits, its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Embodiment 1 Preparation of Astragalus "full components" extract of the present invention

[0041] (1) Get Radix Astragali medicinal material, pulverize after low-temperature drying;

[0042] (2) Soak the Radix Astragali medicinal material powder with 95% ethanol of 10 times the weight volume of the medicinal material for 1 hour, soaking and extracting at 60° C. for 1 hour;

[0043] (3) Filter after cooling to room temperature, collect 95% ethanol extract, add 50% ethanol 10 times the weight and volume of medicinal materials to the dregs, soak and extract at 60°C for 1 hour;

[0044] (4) Filter after cooling to room temperature, collect 50% ethanol extract, add purified water 10 times the weight and volume of medicinal materials to the dregs, soak and extract at 60°C for 1 hour;

[0045] (5) Filter after cooling to room temperature. Combine three extracts, concentrate under reduced pressure until ethanol is completely removed, and then concentrate to an appropriate vo...

Embodiment 2

[0068] Example 2 Comparison of extract yield and main component content of different preparation methods of Astragalus membranaceus According to the methods of the above-mentioned Example 1 and Comparative Examples 1-3, the "full components" extract of Astragalus membranaceus, water extract, and 50% ethanol extract were prepared respectively and 95% ethanol extract.

[0069] (1) Record the weight of the powder obtained after the extract is freeze-dried, and calculate the extraction efficiency according to the following formula:

[0070] Extraction efficiency (%) = weight of extract powder / weight of medicinal material × 100%

[0071] (2) The concentrated sulfuric acid-phenol method was used to determine the content of total polysaccharides in the extract powder obtained by different preparation methods.

[0072] (3) The vanillin-glacial acetic acid method was used to measure the content of total saponins in the extract powder obtained by different preparation methods.

[0073...

Embodiment 3

[0077] Example 3 Comparison of the Efficacy of Different Extracts of Astragalus and Micropowders of Medicinal Materials in Regulating the Immunity of Mice The aqueous extracts of Astragalus membranaceus and micropowdered medicinal materials are the main raw materials of currently commercially available Astragalus membranaceus related products. Here, the water extract of Radix Astragali (prepared in Comparative Example 1), micro-powder of Radix Astragali (purchased by Guizhou Guangjitang Pharmaceutical Co., Ltd.) and Radix Astragali "full components" extract (prepared in Example 1) were compared to mediate mice Efficacy of immune function.

[0078] The ICR mice used in the experiment (half male and half male, 7 weeks old, weighing 18-24 g) were purchased from the Animal Center, Faculty of Health Sciences, University of Macau, and kept in a clean environment with a temperature of 22±1° C. and a humidity of 50-60%. All animal experiments were reviewed and approved by the Animal E...

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Abstract

The invention provides a traditional Chinese medicine "full component" extract with health-care effects, and its composition includes water-soluble and alcohol-soluble components in the traditional Chinese medicine. The invention also provides the preparation method of the "full component" extract of the traditional Chinese medicine and its health care application. The traditional Chinese medicine "full component" extract provided by the invention retains the integrity of the active ingredients and efficacy of the traditional Chinese medicine, is natural, green, healthy and safe; it can be used as a preparation raw material for preparing medicines and health foods, and has wide application value.

Description

Technical field: [0001] The invention relates to an extract of a "full component" of a traditional Chinese medicine, in particular to an extract of a "full component" of a traditional Chinese medicine with health-care effects, and medicines and health foods prepared from the extract. Background technique: [0002] Today, with the accelerated pace of life and the increasing pressure of life, the state of "sub-health" is becoming more and more common. Taking healthy food to improve autoimmunity and improve physical function has become the choice of most people. Healthy foods made from Chinese herbal medicines and their extracts are popular among consumers because of their obvious efficacy and low side effects. The development of new health food based on traditional Chinese medicine and Chinese medicine extract has huge development space and social and economic benefits. [0003] As a treasure of Chinese culture, traditional Chinese medicine has been developed, applied and cl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8988A61K36/8968A61K36/8945A61K36/752A61K36/537A61K36/344A61K36/258A61K36/232A61P39/00A61P37/04A23L33/105A23L33/10
CPCA23V2002/00A61K36/076A61K36/232A61K36/258A61K36/344A61K36/537A61K36/752A61K36/8945A61K36/8968A61K36/8988A61K2236/15A61K2236/17A61K2236/331A61K2236/333A61K2236/39A61K2236/51A23L33/10A23L33/105A61P37/04A61P39/00A23V2200/30A23V2250/208A23V2250/21
Inventor 余华王一涛李摯馨趙冠丁
Owner UNIVERSITY OF MACAU
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