A kind of medical dressing applied to chronic wound and preparation method thereof

Abstract

The invention belongs to the field of medical dressings, and relates to a medical dressing applied to chronic wounds, which includes bacterial cellulose, honey, chitosan and derivatives thereof, and honey and chitosan are formulated as antibacterial agents through physical compounding Compounded on the bacterial cellulose membrane, or through the biocomposite process, adding honey and / or chitosan to the culture medium of the bacterial cellulose film forming process, and then prepared by physical compounding, the three components are all It has good biocompatibility, promotes wound healing and avoids the formation of scars through mutual synergy, and has broad application prospects.

Description

technical field [0001] The invention belongs to the field of medical dressings, in particular to a medical dressing applied to chronic wounds and a preparation method thereof. Background technique [0002] Chronic wound refers to a wound that cannot heal through the normal healing process under the influence of various internal and external factors, and enters a state of pathological inflammatory reaction, which makes the wound difficult to heal for a long time and requires external force to heal. Chronic wounds are often accompanied by bacterial infections, especially the penicillin-resistant Staphylococcus aureus infection, which makes wound infection difficult to control. In addition, there are necrotic tissue in the wound, poor microcirculation, changes in local growth factors and other factors, making the treatment of chronic wounds difficult . In addition to treating the underlying disease, control of wound infection and removal of necrotic tissue are important steps ...

AI Technical Summary

Problems solved by technology

[0005] Patent application CN 103550817 A discloses a bacterial cellulose / chitosan composite sponge dressing. Through the composite action of bacterial cellulose and chitosan, its effect in promoting wound healing is significantly improved, but the sponge dressing also has Adhesives, hot melt adhesives or thermosensitive adhesives are added to help the positioning of the dressing. The existence of the above-mentioned adhesives and other substances poses a greater safety hazard to sensitive skin; another example is the patent application CN 103480027 A which discloses a bacterial cellulose In line with the preparation method of chitosan fiber wet dressing, the patent dissolves bacterial cellulose in an organic solvent, and composites chitosan on the bacterial cellulose film by electrospinning to form bacterial cellulose composite chitosan sugar moist dressing, but the cost of the above-mentioned preparation method is higher; patent application CN 103463124 A discloses a kind of bacterial cellulose chitosan composite gel equally, is made up of chitosan, bacterial cellulose, antibacterial agent and thickener, Among them, the additional antibacterial agents are chemicals, and long-term use is prone to the problem of bacterial resistance

[0006] It can be seen that there are currently many studies on the preparation of bacterial cellulose and chitosan into medical dressings, but some chemical reagents are often added during the preparation process, which limits its application. Therefore, how to choose suitable natural raw materials to prepare a dressing? A kind of medical dressing with excellent antibacterial performance, excellent biological performance and physical and chemical performance is the focus of current research.

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