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Lactobacillus rhamnosus with hyperlipidemia inhibiting effect and application of lactobacillus rhamnosus

A Lactobacillus rhamnosus, hyperlipidemia technology, applied in the field of microorganisms, can solve the problem that the effect of Lactobacillus rhamnosus hyperlipidemia is not reported and the like

Inactive Publication Date: 2019-03-01
NANCHANG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the efficacy of Lactobacillus rhamnosus in inhibiting hyperlipidemia has not yet been reported.

Method used

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  • Lactobacillus rhamnosus with hyperlipidemia inhibiting effect and application of lactobacillus rhamnosus
  • Lactobacillus rhamnosus with hyperlipidemia inhibiting effect and application of lactobacillus rhamnosus
  • Lactobacillus rhamnosus with hyperlipidemia inhibiting effect and application of lactobacillus rhamnosus

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experiment example

[0015] Below in conjunction with accompanying drawing and experimental example, test data, the present invention is described in detail:

[0016] Healthy SD rats, male, weighing 120-150 g, were placed in a feeding environment for adaptation for 1 week. Rats were randomly divided into normal group (ND), high-fat model group (HFD), Lactobacillus rhamnosus CGMCC NO15573 low-dose group (10 8 CFU / mL) and Lactobacillus rhamnosus CGMCC NO15573 high dose group (10 9 CFU / mL) 4 groups, 10 rats in each group. All rats drank water normally, and were given high-fat diets in the model group, high-dose group and low-dose group. According to 10mL / kg body weight, the high-dose group and the low-dose group were given the corresponding dose of Lactobacillus rhamnosus CGMCC NO15573, and the high-fat model group and the normal group were given the same dose of normal saline, for 5 consecutive weeks.

[0017] During the experiment, body weight was weighed regularly, diet and drinking water were ...

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Abstract

The invention provides a lactobacillus rhamnosus with a hyperlipidemia inhibiting effect and an application of the lactobacillus rhamnosus. The strain is lactobacillus rhamnosus NCU2217, collected inCGMCC (China General Microbiological Culture Collection Center) with the collection number of CGMCC NO15573 on April 9, 2018 in No.3, No.1 yard, Beichen West Road, Chaoyang District, Beijing City,. The lactobacillus rhamnosus NO15573 has potential oxidative damage resistance, so that after continuous gavage with the lactobacillus rhamnosus NO15573 for 5 weeks, pancreas injury is reduced, adipocytehypertrophy symptom is relieved, and the strain has functions of inhabiting fatty liver and obesity.

Description

technical field [0001] The invention belongs to the field of microorganisms, and in particular relates to a strain of Lactobacillus rhamnosus capable of inhibiting hyperlipidemia and its application. Background technique [0002] Lactobacillus rhamnosus is a probiotic lactic acid bacterium that has been widely studied abroad in recent years, and it widely exists in traditional fermented dairy products and the human gastrointestinal tract. A large amount of data have shown that Lactobacillus rhamnosus has broad development and application prospects in the field of probiotics. The current research results have confirmed that Lactobacillus rhamnosus has the following beneficial functions: (1) antibacterial effect. According to reports, Lactobacillus rhamnosus has inhibitory effects on some pathogenic bacteria in food and intestines, and the antibacterial substances produced by its fermentation have inhibitory effects on Gram-positive, negative bacteria and various pathogenic b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N1/20A23L33/135C12R1/225
CPCA23L33/135A23V2002/00C12R2001/225C12N1/205A23V2400/175A23V2200/326
Inventor 熊涛谢明勇关倩倩黄涛
Owner NANCHANG UNIV
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