Liquid chromatography combined organic carbon detector and using method thereof

A liquid chromatography and detector technology, applied in the field of water quality analysis and detection, can solve the problems of low time resolution, high difficulty in production and processing, and large volume, and achieve the effects of high time resolution, increased analysis time, and small volume

Pending Publication Date: 2019-03-01
NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] Aiming at the problems existing in the existing size exclusion liquid chromatography-coupled organic carbon detectors such as large volume, high difficulty in manufacturing and processing, and low time resolution, the present invention aims to provide a detector that can be used in combination with liquid chromatography Organic carbon detector by capillary vacuum removal of inorganic carbon, microfluidic UV oxidation of organic carbon and real-time CO 2 Innovations in stripping and other aspects have realized the miniaturization of organic carbon detectors, reduced processing costs, and achieved rapid and sensitive detection

Method used

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  • Liquid chromatography combined organic carbon detector and using method thereof
  • Liquid chromatography combined organic carbon detector and using method thereof
  • Liquid chromatography combined organic carbon detector and using method thereof

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Effect test

Embodiment 1

[0052] This embodiment provides a liquid chromatography coupled organic carbon detector, such as figure 1 As shown, it includes microfluidic reagent injection module 1, inorganic carbon removal module 2, microfluidic ultraviolet oxidation module 3, vacuum system 4, nitrogen carrier gas source 5, pressure and speed regulation module 6, CO 2 Stripping module 7, stripping gas treatment components and CO 2 The gas detector 12 ; the stripping gas processing component further includes a condensation dehumidification module 8 , a halogen removal module 9 , a gas filter 10 and an electronic gas flow meter module 11 .

[0053] Such as figure 2 As shown, the microfluidic reagent injection module 1 includes an acidic agent microfluidic injection pump 101, an acidic agent storage box 102 and a microfluidic pipeline; the acidic agent microfluidic injection pump drives a screw rod through a precision stepping motor to pull a microinjector After extracting the acid agent from the acid age...

Embodiment 2

[0067] This embodiment is basically the same as Embodiment 1, the difference is:

[0068] Such as Figure 4 As shown, the microfluidic reagent injection module 1 only uses the acidic agent microfluidic injection pump 101, the acidic agent storage box 102 and the microfluidic pipeline, and does not use the function of injecting oxidizing agent into the mobile phase, and its oxidation function mainly depends on ultraviolet light. Radiation is irradiated into the microfluidic pipeline 303 to generate strong oxidizing hydroxyl radicals to achieve this.

[0069] Such as Figure 4 As shown, the inorganic carbon removal module 2 adopts a PTFE capillary tube with an inner diameter of 0.25mm and an outer diameter of 1.20mm, and the line length is 10m.

[0070] Such as Figure 4As shown, the microfluidic pipeline 303 in the microfluidic ultraviolet oxidation module 3 adopts a microfluidic quartz chip, the purity of the quartz material used is JGS1 level, the width of the microfluidic...

Embodiment 3

[0073] This embodiment is basically the same as Embodiment 1, the difference is:

[0074] Such as Figure 6 As shown, the microfluidic pipeline 303 in the microfluidic ultraviolet oxidation module 3 adopts a microfluidic quartz chip, the purity of the quartz material used is JGS1 level, the width of the microfluidic groove in the chip is 0.40mm, and the height is 0.20mm , the S-shaped arrangement is densely distributed in the quartz chip, the effective area is 8cm long, 4cm wide, and the total length of the flow path is about 4m; the ultraviolet lamp 301 is suspended and placed under the microfluidic pipeline 303 (ie, the microfluidic quartz chip), with a distance of 2mm ;

[0075] Such as Figure 6 As shown, the nitrogen carrier gas source 5 provides high-purity nitrogen as the carrier gas. After being processed by the pressure regulation and speed regulation module 6, nitrogen at a certain flow rate first passes through the housing 304 of the microflow ultraviolet oxidatio...

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Abstract

The invention belongs to the technical field of water quality analysis detection, and particularly relates to a liquid chromatography combined organic carbon detector and a using method thereof. The organic carbon detector is combined with a size exclusion chromatography system for use and comprises a decarbonizing oxidation subsystem and a nitrogen-blowoff CO2 detection subsystem which are in sequential connection, in independent arrangement and detachable connection through a pipeline and a connector. Organic carbon oxidation and CO2 blowoff can be performed at the same time continuously bydividing oxygen of organic carbon and blowoff of CO2 into two modules, namely a microflow ultraviolet oxidation module and a CO2 blowoff module and prolonging oxidation time of organic matters in a mobile phase in a form of a spiral capillary quartz tube or a microfluidic quartz chip so as to realize continuous detection of CO2.

Description

technical field [0001] The invention belongs to the technical field of water quality analysis and detection, and in particular relates to a liquid chromatography-coupled organic carbon detector and a use method thereof. Background technique [0002] Dissolved organic matter (DOM) is a general term for a series of complex and highly heterogeneous soluble compounds in soil, sediment and water, including protein biopolymers, humic acid, fulvic acid, and building block organic matter. and some small molecules. Size exclusion liquid chromatography is an important method to analyze and characterize the composition and molecular weight distribution of dissolved organic compounds. Macromolecular substances are excluded from the outside of the pores of the resin filler and the elution time is shorter, while small molecular substances enter the inner pores of the resin filler and the elution time is longer. The dissolved organic matter separated by the size exclusion chromatography ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/88G01N30/40
CPCG01N30/40G01N30/88G01N2030/402G01N21/3504G01N21/61G01N30/62G01N2030/884G01N30/74G01N2030/645G01N21/33G01N2030/8854
Inventor 李文涛季闻翔李爱民蔡珉晖吴亚萍李燕程士吴几吴吉春左延婷韩玉泽
Owner NANJING UNIV
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