Method for testing in-vitro anti-acid performance of magnesium-containing inorganic antacid
An antacid and inorganic technology, which is applied in the field of testing the anti-acid performance of magnesium-containing inorganic antacids in vitro, can solve the problems of insufficient and comprehensive anti-acid performance, and achieve the effects of simple operation, quick evaluation, and easy implementation
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Embodiment 1、2、3
[0029] Embodiments 1, 2, and 3: Take three dissolution cups of RC12AD dissolution tester, code them as No. 1, No. 2, and No. 3 in turn, add 200ml of dilute hydrochloric acid with a pH value of 1.0 (20°C) respectively, and place them in a water bath Heat it under stirring at 400rpm, keep the temperature for 30min after the temperature reaches 36°C-38°C, measure and record the pH value at this time. Get three aluminum magnesium carbonate crude drug samples, each accurately weighs 4.0g, adds the above-mentioned liquids successively, starts timing, and records the change situation of the pH value with time, relevant test results are shown in Table 1 and figure 1 .
[0030] At the same time, at 5 minutes, 10 minutes, 20 minutes, 40 minutes, 60 minutes, 12 hours, 24 hours, 48 hours, 72 hours, and 96 hours, take 1ml of the reaction solution with a syringe, filter it through a filter membrane, and use EDTA The concentration of magnesium ions in the filtrate was detected by complexo...
Embodiment 7、8、9
[0045] Embodiment 7, 8, 9: get 3 100ml Erlenmeyer flasks and number them as No. 7, No. 8, and No. 9 successively, add 25ml of dilute hydrochloric acid with a pH value of 1.0 (20°C) successively, and a pH value of 1.0 (20°C) 25ml of dilute hydrochloric acid and 25ml of dilute hydrochloric acid with a pH value of 3.0 (20°C), placed in a water bath and heated with stirring at 100rpm. After the temperature reached 36°C-38°C, keep the temperature for 15min, measure and record the pH value at this time. Accurately weigh 0.5g, 1.0g, 0.5g of aluminum and magnesium plus raw materials in turn, add the above liquids in turn, start timing, and record the change of pH value with time. The specific test results are shown in Table 5.
[0046] After continuing to stir for 24 hours, filter, get the filtrate to check the stripping situation of magnesium ions successively, the detection method that adopts is EDTA complexometric titration. The specific test results are shown in Table 6.
[0047]...
Embodiment 10、11、12
[0053] Embodiment 10, 11, 12: Get 3 1000ml Erlenmeyer flasks, number them as No. 10, No. 11 and No. 12 successively, add 1000ml of distilled water with a pH value of 7.0 (20°C) and a pH value of 1.0 (20°C) respectively 1000ml of dilute nitric acid and 1000ml of dilute acetic acid with a pH value of 3.0 (20°C) were placed in a water bath and heated under stirring at 1000rpm. After the temperature reached 34°C to 39°C, the temperature was maintained for 100min, and the pH value at this time was measured and recorded. Accurately weigh 3 parts of 20.0g magnesium hydroxide bulk drug, add the above-mentioned liquids in sequence, start timing, and record the change of pH value with time. The relevant test results are shown in Table 7.
[0054] After continuing to stir for 48 hours, filter, get the filtrate to check the stripping situation of magnesium ions successively, and adopt EDTA complexometric titration to detect. The specific test results are shown in 8.
[0055] After adding...
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