Application of iron removal drug in preparation of H7N9 bird flue preventive drugs
A bird flu and drug technology, applied in the field of biomedicine, can solve the problems of weak iron ion scavenging effect and inability to remove iron ions
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[0030] The present invention is further described below in conjunction with specific embodiment, but protection scope of the present invention is not limited thereto:
[0031] Desferrioxamine: desferrioxamine B, a chelating agent, mainly complexes with trivalent ions and trivalent aluminum ions to form complexes, and the complex formation constants are 1031 and 1025 respectively; but for divalent ions such as ferrous (Fe++ ), copper (Cu++), zinc (Zn++) and calcium (Ca++), etc. have very low affinity, and their complex formation constants are 1014 or lower. Chelation is performed on a 1:1 molar basis.
[0032] Experiment 1. Low serum iron content in patients infected with H7N9 avian influenza:
[0033] 1.1 Serum samples
[0034] Serum samples were selected from: 42 serum samples of H7N9 avian influenza patients and 83 normal human serum samples.
[0035] These serum samples were all from the First Affiliated Hospital of Zhejiang University School of Medicine. Among them, the...
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