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Application of iron removal drug in preparation of H7N9 bird flue preventive drugs

A bird flu and drug technology, applied in the field of biomedicine, can solve the problems of weak iron ion scavenging effect and inability to remove iron ions

Inactive Publication Date: 2019-03-15
ZHEJIANG UNIV
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0005] Desferrioxamine can remove iron ions in ferritin and hemosiderin, but it has a weak effect on removing iron ions in transferrin, let alone remove iron ions in hemoglobin, myosin and cytochrome

Method used

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  • Application of iron removal drug in preparation of H7N9 bird flue preventive drugs
  • Application of iron removal drug in preparation of H7N9 bird flue preventive drugs

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Experimental program
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Embodiment Construction

[0030] The present invention is further described below in conjunction with specific embodiment, but protection scope of the present invention is not limited thereto:

[0031] Desferrioxamine: desferrioxamine B, a chelating agent, mainly complexes with trivalent ions and trivalent aluminum ions to form complexes, and the complex formation constants are 1031 and 1025 respectively; but for divalent ions such as ferrous (Fe++ ), copper (Cu++), zinc (Zn++) and calcium (Ca++), etc. have very low affinity, and their complex formation constants are 1014 or lower. Chelation is performed on a 1:1 molar basis.

[0032] Experiment 1. Low serum iron content in patients infected with H7N9 avian influenza:

[0033] 1.1 Serum samples

[0034] Serum samples were selected from: 42 serum samples of H7N9 avian influenza patients and 83 normal human serum samples.

[0035] These serum samples were all from the First Affiliated Hospital of Zhejiang University School of Medicine. Among them, the...

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Abstract

The invention relates to the medicine of biological medicine, and relates to application of an iron removal drug in the preparation of H7N9 bird flue preventive drugs. The invention discloses application of the iron removal drug in the preparation of H7N9 bird flue preventive drugs. The iron removal drug is deferoxamine; the deferoxamine can be used for preventing and / or curing H7N9 bird flue, that is, the content of serum iron for a patient is reduced by the deferoxamine, so that the effect of preventing H7N9 bird flue is reached.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to the application of deferoxamine, an iron-removing drug, in the preparation of drugs for preventing and treating H7N9 avian influenza. Background technique [0002] H7N9 avian influenza is an avian influenza virus belonging to the genus Influenza A in the Orthomyxoviridae family. The H7N9 subtype avian influenza virus is a new type of reassortant virus, and its internal genes are derived from the H9N2 avian influenza virus. The main source of infection of the virus is live poultry. After human contact with the virus source of infection, avian influenza infection will occur. After being infected with the H7N9 avian influenza virus, acute respiratory infectious disease symptoms appear, mainly manifested as fever, cough, sputum, chest pain, shortness of breath. Difficulties, etc. At present, there is no specific vaccine against H7N9 avian influenza, and its pathogenesis still needs to be ...

Claims

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Application Information

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IPC IPC(8): A61K31/16A61P31/16
Inventor 王福俤周继勇魏家玙王海龙
Owner ZHEJIANG UNIV
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