Treatment of vascular calcification
A technology of vascular calcification and solvate, which is used in the field of compounds for the treatment of medial vascular calcification or intimal atherosclerotic calcification, and can solve problems such as adverse effects on mechanical properties of vascular tissue and matrix hardening.
Active Publication Date: 2019-03-15
CAMBRIDGE ENTERPRISE LTD +1
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- Abstract
- Description
- Claims
- Application Information
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Problems solved by technology
Calcification leads to hardening of the matrix, which is essential for bone but has an adverse effect on the mechanical properties of vascular tissue
Method used
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Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0133] Example 1: Demonstration of the physiological link between poly(ADP ribose) (PAR) and vascular calcification;
Embodiment 2
[0134] Embodiment 2: detecting the toxicity of PARP inhibitor / tetracycline to bovine vascular smooth muscle cells;
Embodiment 3
[0135] Embodiment 3: Detect the toxicity of PARP inhibitor / tetracycline to human monocyte macrophage;
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The invention relates to the use of a poly(ADP ribose) polymerase (PARP) inhibitor and / or a tetracycline, for treating, preventing or ameliorating medial vascular calcification or intimal atherosclerotic calcification, and to pharmaceutical compositions comprising PARP inhibitors or tetracycline.
Description
technical field [0001] The present invention relates to vascular calcification, and in particular to compounds useful in the treatment of diseases associated with excessive and / or inappropriate vascular calcification. In particular, the invention relates to the treatment of medial vascular calcification or intimal atherosclerotic calcification. The present invention relates to pharmaceutical compositions and methods for the treatment of excessive and / or inappropriate (ie, medial) vascular calcification. Background technique [0002] Vascular calcification is associated with a range of diseases and can be broadly classified into three distinct types, namely (1) intimal atherosclerotic calcification, which is intimal calcification and includes atherosclerosis and associated inflammation; (2) valvular calcification aortic stenosis, which is calcification of the aortic valve; and (3) medial calcification, which is calcification of the media, see Demer and Tintut "Vascular Calci...
Claims
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IPC IPC(8): A61K31/4184A61K31/454A61K31/4709A61K31/502A61K31/5025A61K31/55A61K31/65A61K45/06A61P9/10A61P9/14
CPCA61K45/06A61K31/4184A61K31/454A61K31/502A61K31/5025A61K31/55A61K31/47A61K31/50A61K31/166A61K31/4709A61K31/473A61K31/506A61K31/519A61K31/522A61K31/554A61K31/65A61P43/00A61P9/00A61P9/10A61P9/14A61K2300/00
Inventor M·杜尔D·里德C·沙纳汉
Owner CAMBRIDGE ENTERPRISE LTD
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