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Application of methyl palmitate in preparation of drugs for preventing or treating fatty liver

A technology for methyl palmitate and steatohepatitis, applied in the directions of drug combination, ester active ingredients, digestive system, etc., can solve problems such as no literature report of methyl palmitate, and medical use to be investigated.

Active Publication Date: 2021-03-19
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, no literature has reported that methyl palmitate has the effect of treating non-alcoholic fatty liver disease, and more medical uses of methyl palmitate remain to be investigated

Method used

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  • Application of methyl palmitate in preparation of drugs for preventing or treating fatty liver
  • Application of methyl palmitate in preparation of drugs for preventing or treating fatty liver
  • Application of methyl palmitate in preparation of drugs for preventing or treating fatty liver

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Objective: The effect of methyl palmitate on liver histology of non-alcoholic fatty liver animals model

[0027] Experimental animals: Use C57BL / 6J mice, male, weight (20 ± 2) g.

[0028] Experimental method: When the mouse was long to 8 weeks (20 ± 2 g), mice were randomly divided into 5 groups, 10 per group. In the first group, normal feed is given as a blank control group (Control); the second group gives MCD diet, as a model group (MODEL); the remaining groups, at 75 mg / kg / day, 150mg while giving MCD diet The dose of / kg / day, 300 mg / kg / day was administered to palmitate, respectively as a low concentration pharmaceutical group (MP 1), a medium concentration pharmaceutical group (MP 2), high concentration pharmaceutical group (MP 3). The low high-and high pharmaceutical group is administered in a gastrointestinal approach. All mice were free to eat, drink water, and light 12h. Mice were recorded once a week, 6 weeks were fed continuously, 10% hydrated chlorof...

Embodiment 2

[0036] Experimental purpose: Effects of methyl palmitate on the biochemical indicators of non-alcoholic fatty liver animal model

[0037] Experimental animals: Use C57BL / 6J mice, male, weight (20 ± 2) g.

[0038] Experimental method: When the mouse was long to 8 weeks (20 ± 2 g), mice were randomly divided into 5 groups, 10 per group. In the first group, give normal feed as a blank control group (Control); the second group gave MCD diet as a model group (model); the remaining groups, at 75 mg / kg / day while giving MCD diet The dose of 150 mg / kg / day, 300 mg / kg / day was given methyl palmitate, respectively as a low concentration of pharmaceutical group (MP 1), a medium concentration pharmaceutical group (MP 2), high concentration pharmaceutical group (MP 3). The low high-and high pharmaceutical group is administered in a gastrointestinal approach. All mice were free to eat, drink water, and light 12h. Mice were recorded once a week, 6 weeks were fed continuously, 10% hydr...

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Abstract

The invention discloses application of methyl palmitate in preparing a drug for preventing or treating fatty liver. Compared with the prior art, the invention finds that the methyl palmitate can be used for preventing or treating the fatty liver and particularly for non-alcohol fatty liver for the first time, and the treatment effect is significant. The research proves that the methyl palmitate can alleviate the liver fatty degeneration, inflammation and fibrosis, can alleviate the abnormal accumulation of liver lipid and can reduce the oxidation stress.

Description

Technical field [0001] The present invention belongs to the technical field of drug use, and therefore specifically, the application of methyl palmitate is prepared or therapeutic in the treatment of fatty liver drugs. Background technique [0002] Non-alcoholic fatty liver (NAFLD) is a clinical pathological syndrome characterized by non-alcoholic alcoholism, characterized by lipophilic degeneration and lipid storage. His pathological changes have shown simple fatty liver, fatty hepatitis, fatty liver fibrosis and cirrhosis. NAFLD's common diseases have obesity, type II diabetes, hyperlipidemia, hypertension. A large number of studies have confirmed the correlation between non-alcoholic fatty liver and cardiovascular disease. Liver disease and atherosclerosis may be mediated by inflammation of visceral adipose tissue, in which case the liver has played a role in responses to the abnormal conditions of the whole body and produces related factors that cause atherosclerosis. Non-alc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/23A61P1/16
CPCA61K31/23A61P1/16
Inventor 徐晓军李慧霞张丽
Owner CHINA PHARM UNIV
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