Unlock instant, AI-driven research and patent intelligence for your innovation.

Chalcone double Mannich base compound, its preparation method and use

A technology of chalcone double Mannich base and double Mannich base, which is applied in the field of chalcone double Mannich base compounds, their preparation and application, and can solve the problem of poor long-term curative effect and action target of AD patients Single, many side effects and other issues

Active Publication Date: 2022-04-22
SICHUAN UNIV
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these drugs have problems such as a single target, more toxic and side effects in clinical use, and poor long-term curative effect on AD patients.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Chalcone double Mannich base compound, its preparation method and use
  • Chalcone double Mannich base compound, its preparation method and use
  • Chalcone double Mannich base compound, its preparation method and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1 General method for the preparation of chalcone double Mannich base compound (I)

[0034] Add 2.0 mmol of the corresponding hydroxyacetophenone Mannich base compound (1), 2.5 mmol of the corresponding hydroxybenzaldehyde Mannich base compound (2) and 30 ml of ethanol into the reaction flask, stir well, and add dropwise 30% KOH aqueous solution 15.0 mmol, stirred and reacted at room temperature for 2.0 to 48.0 hours (the reaction process was followed by TLC); after the reaction, cooled to room temperature, adjusted the pH of the reaction solution to strong acidity with 10% hydrochloric acid aqueous solution, and then saturated sodium bicarbonate aqueous solution Adjust the pH of the reaction solution to weak alkalinity, evaporate ethanol under reduced pressure, add 80 mL of deionized water to the residual liquid, and extract three times with 240 mL of dichloromethane. After drying with sodium sulfate, filter, evaporate the solvent under reduced pressure, and ...

Embodiment 2

[0041] Example 2 Preparation method of chalcone double Mannich base compound (I) and acid salt formation

[0042] Add 2.0 mmol of the chalcone double Mannich base compound (I) obtained in the above-mentioned Example 1 and 50 ml of acetone into the reaction flask, stir evenly, add 8.0 mmol of the corresponding acid, heat and reflux and stir for 20 minutes, and react After cooling to room temperature, the solvent is evaporated under reduced pressure to obtain the salt of chalcone bis-Mannich base compound (I), whose chemical structure is 1 Confirmed by H NMR and ESI-MS.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a new type of chalcone double Mannich base compound (I) and its pharmaceutically acceptable salt, its preparation method, pharmaceutical composition and medicine for treating and / or preventing nervous system related diseases. Including, but not limited to, vascular dementia, Alzheimer's disease, Parkinson's disease, Huntington's disease, HIV-related dementia, multiple sclerosis, amyotrophic lateral sclerosis, neuropathic pain, glaucoma , ischemic stroke, hemorrhagic stroke, and nerve damage caused by traumatic brain injury;

Description

technical field [0001] The invention belongs to the field of medicinal chemistry, and relates to a new class of chalcone double Mannich base compounds (I) and pharmaceutically acceptable salts thereof, their preparation methods, pharmaceutical compositions and preparations for the treatment and / or prevention of neurological disorders. Use in drugs for system-related diseases, including but not limited to vascular dementia, Alzheimer's disease, Parkinson's disease, Huntington's disease, HIV-related dementia, multiple sclerosis, amyotrophic lateral sclerosis, neurological Sexual pain, glaucoma, ischemic stroke, hemorrhagic stroke, and neurological damage caused by traumatic brain injury. Background technique [0002] Neurodegenerative diseases refer to the general term for diseases caused by chronic progressive degeneration of central nervous tissue, including Alzheimer's disease (Alzheimer's disease, AD), Parkinson's disease (Parkinson's disease, PD), Huntington's disease (H...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C07C225/16C07D295/112C07D211/14C07C221/00A61P9/10A61P25/28A61P25/16A61P25/14A61P25/04A61P25/00A61P29/00A61P27/06A61P39/06
CPCA61P9/10A61P25/00A61P25/04A61P25/14A61P25/16A61P25/28A61P27/06A61P29/00A61P39/06C07C225/16C07D211/14C07D295/112
Inventor 邓勇田超全宋青曹忠诚
Owner SICHUAN UNIV