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Application of astragalus mongholicus and flavone extract in preparation of chemotherapy drugs for laryngocarcinoma

A technology of astragalus flavonoids and chemotherapeutic drugs is applied in the application field of astragalus flavonoids extract in the preparation of chemotherapeutic drugs for laryngeal cancer, and can solve the problems of no chemotherapeutic drugs for laryngeal cancer and the like.

Inactive Publication Date: 2019-05-10
FIRST HOSPITAL OF SHANXI MEDICAL UNIV +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no report on the use of astragalus flavonoids and its extracts in chemotherapy drugs for laryngeal cancer, and there is no application of extracts mainly composed of the above active ingredients for the preparation of chemotherapy drugs for laryngeal cancer.

Method used

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  • Application of astragalus mongholicus and flavone extract in preparation of chemotherapy drugs for laryngocarcinoma
  • Application of astragalus mongholicus and flavone extract in preparation of chemotherapy drugs for laryngocarcinoma
  • Application of astragalus mongholicus and flavone extract in preparation of chemotherapy drugs for laryngocarcinoma

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Embodiment 1

[0026] The application of the extract of astragalus flavonoids in the preparation of chemotherapy drugs for laryngeal cancer, the chemotherapy drugs are composed of extracts of astragalus flavones and cisplatin, and the mass ratio of the extracts of astragalus flavones to cisplatin is not lower than 6:1. The astragalus flavonoids extract is the ethanol extract of Astragalus membranaceus. The mass percent content of flavonoids in the described astragalus flavonoids extract is 40%, which is a mass percent, and the main chemical components contained include formononetin, formononetin, acteosin, acteosin-7-O-β- D-glucopyranose, 7,2′-dihydroxy-3′,4′-dimethoxyisoflavan, 2′-hydroxy-3′,4′-dimethoxyisoflavan-7-O -β-D-glucopyranose, 3-Hydroxy-9,10-dimethoxypterostalane, 9,10-dimethoxypterostalane-3-O-β-D-glucopyranose. The described astragalus flavonoids extract is prepared by the following steps:

[0027] a. Take 3000g of Radix Astragali medicinal material, add 8L of water to heat an...

Embodiment 2

[0031] The application of the extract of astragalus flavonoids in the preparation of chemotherapy drugs for laryngeal cancer, the chemotherapy drugs are composed of extracts of astragalus flavones and cisplatin, and the mass ratio of the extracts of astragalus flavones to cisplatin is not lower than 6:1. The astragalus flavonoids extract is the ethanol extract of Astragalus membranaceus. The mass percent content of flavonoids in the described astragalus flavonoids extract is 50%, which is a mass percent, and the main chemical components contained include formononetin, formononetin, calycosin, calycosin-7-O-β- D-glucopyranose, 7,2′-dihydroxy-3′,4′-dimethoxyisoflavan, 2′-hydroxy-3′,4′-dimethoxyisoflavan-7-O -β-D-glucopyranose, 3-Hydroxy-9,10-dimethoxypterostalane, 9,10-dimethoxypterostalane-3-O-β-D-glucopyranose. The described astragalus flavonoids extract is prepared by the following steps:

[0032] a. Take 1000g of Radix Astragali medicinal material, add 8L of ethanol with a...

Embodiment 3

[0036] The application of the extract of astragalus flavonoids in the preparation of chemotherapy drugs for laryngeal cancer, the chemotherapy drugs are composed of extracts of astragalus flavones and cisplatin, and the mass ratio of the extracts of astragalus flavones to cisplatin is not lower than 6:1. The astragalus flavonoids extract is the ethanol extract of Astragalus membranaceus. The mass percent content of flavonoids in the described astragalus flavonoids extract is 60%, which is a mass percent, and the main chemical components contained include formononetin, formononetin, acteosin, acteosin-7-O-β- D-glucopyranose, 7,2′-dihydroxy-3′,4′-dimethoxyisoflavan, 2′-hydroxy-3′,4′-dimethoxyisoflavan-7-O -β-D-glucopyranose, 3-Hydroxy-9,10-dimethoxypterostalane, 9,10-dimethoxypterostalane-3-O-β-D-glucopyranose. The described astragalus flavonoids extract is prepared by the following steps:

[0037] a. Take 1000g of Radix Astragali medicinal material, add 8L of ethanol with a v...

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Abstract

The invention relates to novel usage of an astragalus mongholicus and flavone extract, in particular to application of the astragalus mongholicus and flavone extract in preparation of chemotherapy drugs for laryngocarcinoma. The chemotherapy drugs are composed of an ethanol extract of astragalus mongholicus and cisplatin, and the mass ratio of the ethanol extract of the astragalus mongholicus to the cisplatin is not less than 6:1. The laryngocarcinoma is the second largest respiratory high-incidence tumor after lung cancers, and is highly prevalent in northern China, an I type recommended drugfor the laryngocarcinoma chemotherapy is the cisplatin, and the dose-dependent nephrotoxicity of the cisplatin greatly limits its clinical application. The extract enhances the tumor suppressing ability, and the astragalus mongholicus and the flavone have a good protective effect on the kidney damage caused by the cisplatin.

Description

technical field [0001] The invention relates to a new application of the astragalus flavone extract, in particular to the application of the astragalus flavone extract in preparing chemotherapy drugs for laryngeal cancer. Background technique [0002] Laryngocarcinoma is the second most common respiratory tumor after lung cancer. It is highly prevalent in northern China. Cisplatin is the recommended class I chemotherapy drug for laryngeal cancer. However, the dose-dependent nephrotoxicity of cisplatin greatly limits its clinical application. Cisplatin mainly damages the proximal renal tubular epithelial cells through oxidative stress, mitochondrial damage and inflammatory response to cause acute or chronic renal failure. [0003] Astragalus is one of the commonly used Chinese herbal medicines. It was first recorded in "Shen Nong's Materia Medica". According to literature reports (Song Yan et al., Modern Oncology Medicine, 2013, 21(7):1419-1421), Astragalus can regulate the ...

Claims

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Application Information

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IPC IPC(8): A61K36/481A61P35/00A61P11/04A61P13/12A61K33/243
Inventor 高伟李震宇吴勇延崔佳佳王斌全温树信张春明刘红亮郑希望薛绪亭牛敏张宇良胡汪来
Owner FIRST HOSPITAL OF SHANXI MEDICAL UNIV
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