Drug composition for treating bladder carcinoma and application thereof

A composition and technology for bladder cancer, applied in the field of pharmaceutical compositions for bladder cancer treatment, can solve problems such as high toxicity and cardiotoxicity, and achieve the effects of less toxicity, less toxic side effects, and reduced cardiotoxicity

Active Publication Date: 2019-05-14
深圳市龙华区人民医院 +1
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

Doxorubicin has a broad antitumor spectrum and good curative effect; however, the drug is highly toxic, and long-term use can easily induce severe cardiotoxicity

Method used

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  • Drug composition for treating bladder carcinoma and application thereof
  • Drug composition for treating bladder carcinoma and application thereof
  • Drug composition for treating bladder carcinoma and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0044] 1. Materials and methods

[0045] 1. Main material

[0046] The cell lines used in this experiment include: bladder cancer cell lines SW780, T24, and normal bladder urothelial cells SV-HUC-1. Among them, bladder cancer cell lines SW780 and T24 were purchased from American Type Culture Collection (ATCC, Manassas, USA), and SV-HUC-1 was isolated and cultured from normal bladder urothelial cells.

[0047] The basal medium in this example is composed of 90% DMEM medium and 10% fetal bovine serum, both of which are purchased from Life technology, USA. Unless otherwise specified, the medium mentioned in the following experiments of this example is the basal medium. The test medium in this example is formed by adding EGCG and / or DOX on the basis of basal medium or DMEM medium, and is used to test the influence of EGCG and / or DOX on cells. The specific amount of EGCG and / or DOX added is detailed See individual tests below.

[0048] In addition, 1%-2% glutamine and 0.5%-1% d...

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PUM

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Abstract

The invention discloses a drug composition for treating bladder carcinoma and application thereof. The drug composition for treating bladder carcinoma is composed of active components of doxorubicin and epigallocatechin gallate. According to the drug composition, through the synergistic bladder carcinoma prevention effect of EGCG and DOX, the overall cardiotoxicity of the drug composition is lowered, and the toxic and side effect on normal bladder uroepithelium cells is small. Compared with a method of single adoption of DOX, the drug composition has the advantages that the better effect of inhibiting the growth of bladder carcinoma cells is achieved, migration and infection of the bladder carcinoma cells can be better inhibited, and the better effect of inducing apoptosis of the bladder carcinoma cells is achieved. According to the drug composition, a new drug with a better carcinoma resisting effect and lower toxicity is provided for treating bladder carcinoma.

Description

technical field [0001] The application relates to the field of medicines for treating bladder cancer, in particular to a pharmaceutical composition for treating bladder cancer and its application. Background technique [0002] Bladder cancer refers to the most common malignant tumor of the urinary system that occurs on the bladder mucosa, and is also one of the ten most common tumors in the human body. Bladder cancer ranks first in the incidence of genitourinary system tumors in my country. Bladder cancer can even occur in children, and the incidence rate increases with age, with the highest incidence age being 50-70 years old. [0003] Doxorubicin (abbreviated as DOX) is a commonly used cancer chemotherapy drug, and it is also a first-line chemotherapy drug for bladder cancer. Doxorubicin has a broad antitumor spectrum and good curative effect; however, the drug is highly toxic, and long-term use can easily induce severe cardiotoxicity. Therefore, finding a combination t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61K31/353A61P35/00
Inventor 罗可望罗新乐黄卫人
Owner 深圳市龙华区人民医院
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