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Method for quickly forming amine groups on the surface of materials, medical materials with high-density amine groups on the surface and their applications
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An amine-based, rapid technology, applied in medical science, surgery, coating, etc., can solve the problems of long production cycle, complicated method, unfavorable industrial application, etc., achieve short reaction time, simple and easy preparation method, meet the requirements of amine-based Effect of Density Requirements
Active Publication Date: 2020-06-26
SOUTHWEST JIAOTONG UNIV
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[0003] The existing method of introducing amine groups on the surface of materials mainly uses the method of building a surface rich in amine groups. This method is relatively complicated and has a long production cycle, which is not conducive to industrial application.
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Embodiment 1
[0041] This embodiment provides a method for rapidly forming amine groups on the surface of a material, which includes the following steps:
[0042] After polished and cleaned, the titanium sheet was soaked in 1mol / L potassiumhydroxide solution, kept at 70°C for 10h, then ultrasonically cleaned twice with RO water, kept at 70°C for 10h, and then placed in the Dry at 50°C for later use.
[0043] Alkali-activated material was mixed with PAMAM-NH at a concentration of 0.01 mg / mL 2 The solution (molecular weight is about 6900) was reacted at 3°C for 5 minutes, then washed with RO for 3 times, and the ear balls were washed and dried for use.
Embodiment 2
[0045] This embodiment provides a method for rapidly forming amine groups on the surface of a material, which includes the following steps:
[0046] After polished and cleaned, the titanium sheet was soaked in a 5mol / L sodiumhydroxide solution, kept at 90°C for 14h, then ultrasonically cleaned with RO water for 4 times, kept at 90°C for 14h, and then placed in the Dry at 50°C for later use.
[0047] The base-activated material was mixed with PAMAM-NH at a concentration of 1 mg / mL 2 The solution (molecular weight is about 14300) was reacted at a temperature of 10°C for 24 hours, then washed with RO for 3 times, and the earballs were washed and dried for use.
Embodiment 3
[0049] This embodiment provides a method for rapidly forming amine groups on the surface of a material, which includes the following steps:
[0050] After polished and cleaned, the titanium sheet was soaked in 3mol / L sodiumhydroxide solution, kept at 80°C for 12h, then ultrasonically cleaned with RO water for 4 times, kept at 80°C for 12h, and then placed in the Dry at 50°C for later use.
[0051] Alkali-activated material was mixed with PAMAM-NH at a concentration of 0.1 mg / mL 2 The solution (molecular weight is about 6909) was reacted at a temperature of 5°C for 30 minutes, then washed with RO for 3 times, and the ear balls were blown dry for use.
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Abstract
The invention discloses a method for rapidly forming an amine group on the surface of a material, a medical material with a surface loaded with a high-density amine group and an application of the medical material, and relates to the technical field of medical materials. The method for rapidly forming the amine group on the surface of the material comprises the steps that the to-be-loaded materialis subjected to standing in an alkaline solution to obtain an alkali-activated material; the alkali-activated material reacts with a PAMAM-NH2 solution for 5min-24h. The medical material with the surface loaded with the high-density amine group comprises the to-be-loaded material, the surface of the to-be-loaded material is loaded with PAMAM-NH2, and the medical material can be prepared through the method. The preparation method is simple and easy to operate, the reaction time is short, the density of the amine groups on the surface of the material can be effectively controlled, and the requirements of different amine group densities on the surface of the material can be met.
Description
technical field [0001] The invention relates to the technical field of medical materials, and in particular to a method for rapidly forming amine groups on the surface of materials, a medical material with high-density amine groups loaded on the surface and applications thereof. Background technique [0002] Regulating the biological function of implanted materials is an important content in the study of implanted materials. It is an effective means to introduce functional molecules on the surface of materials. It is the research to transform the inert surface into the active surface with the immobilization effect of biological functional molecules. Base. Ti-based biomaterials are widely used in the field of biomedicine. At present, the bridging of functional molecules is mainly achieved through silane molecules and dopamine. [0003] The existing methods for introducing amine groups on the surface of materials mainly use the surface construction method of rich amine groups...
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