Novel marker of liver cirrhosis or liver fibrosis

A technology for substances and liver diseases, applied in the field of biomedicine, can solve problems such as disagreement on the role of GP73
CN109765378AActive Publication Date: 2019-05-17鲁凤民 +2
18 Cites 3 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
鲁凤民
Publication Date
2019-05-17

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention relates to the field of diagnosis and treatment of liver cirrhosis and liver fibrosis, in particular to a Golgi protein 73 (GP73) and application of substances for detecting the concentration of the Golgi protein 73 (GP73) to preparation of a product for screening or assisting diagnosis of liver cirrhosis-related or liver fibrosis-related diseases or a product for assisting determination of the prognosis of the diseases. It is proved that the Golgi protein 73 (GP73) can be used as a novel marker of liver cirrhosis, has diagnostic value especially for liver cirrhosis caused by non-hepatitis B virus infection, and has no diagnostic value for primary liver cancer.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention belongs to the field of biomedicine, and relates to a new application of a substance for detecting the concentration of Golgi protein 73 (GP73) and an application of the Golgi protein 73 (GP73) in preparing products for screening and diagnosing liver cirrhosis or liver fibrosis. Background technique

[0002] In 2000, Kladney et al. discovered Golgi protein 73 (GP73) when studying adult giant cell hepatitis, and it has been 16 years so far (Kladney RD, Bulla GA, Guo L, et al. Gene. 65). GP73 is a transmembrane glycoprotein with 402 amino acids and a relative molecular weight of 73kDa, also known as type II Golgi membrane protein (Golgiphosphoprotein 2, Golph2) and Golgi membrane protein 1 (Golgi membrane protein 1, Golm1). It is usually located in the trans-Golgi complex, and the gene encoding GP73 protein is located on chromosome 9, with a total length of 3080 nucleotides, and the coding region is located at 199-1404nt. GP73 is expresse...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More