Application of clostridium butyricum in preparing preparation for inducing antitumor immunity and enhancing sensitivity of immune checkpoint inhibitor

An immune checkpoint and anti-tumor immune technology, applied in the field of biomedicine, can solve the problems of increasing the response rate and treatment effect of immune checkpoint inhibitors, adverse reactions of the digestive tract, and the inability to obtain clinical benefits, etc.

Active Publication Date: 2019-05-21
QINGDAO EASTSEA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Current medical research believes that continuous treatment of immune checkpoint blockade can bring better therapeutic effect. However, in patients with limited immune checkpoint response, strong side effects such as severe gastrointestinal adverse reactions, severe skin itching, Liver injury, pneumonia, renal impairment, etc. make these patients have to suspend immunotherapy, so that they cannot obtain the ex

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  • Application of clostridium butyricum in preparing preparation for inducing antitumor immunity and enhancing sensitivity of immune checkpoint inhibitor
  • Application of clostridium butyricum in preparing preparation for inducing antitumor immunity and enhancing sensitivity of immune checkpoint inhibitor

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preparation Embodiment 1

[0033] Preparation Example 1 The preparation of Clostridium butyricum powder

[0034] 1 Preparation of bacteria powder and identification of strains

[0035] Take a human feces sample, then put the sample in a sterilized anaerobic bottle, blow in nitrogen gas and mix well at the same time, quickly take 2 grams of sample from it and add it to 18 mL of sterilized diluent, blow in nitrogen gas and mix well at the same time, In the bacteria operating table, carry out 10 -1 、10 -2 、10 -3 、10 -4 , 10 -5 , 10 -6 , 10 -7 Gradient dilution, take 10 -5 , 10 -6 , 10 -7 Three dilution gradients were spread on the solid medium for the selective single colony isolation of Clostridium butyricum, placed in an anaerobic tank, cultured at 37°C for 48 hours, and selected single colonies with good growth were inoculated in the liquid amplification In the culture medium, place it in an anaerobic tank, and anaerobically expand and cultivate at 37° C. for 48 hours. Centrifuge the obtained...

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Abstract

The invention discloses application of clostridium butyricum in preparing a preparation for inducing antitumor immunity and enhancing sensitivity of an immune checkpoint inhibitor. Specifically, the clostridium butyricum serves as a main active ingredient to be prepared into a drug and other biological preparations, and the drug or other biological preparations are combined with the immune checkpoint inhibitor for treating cancers. By means of the preparation, the antitumor immunity can be effectively induced, the response rate and treatment effect of the immune checkpoint inhibitor are improved, the side effects are lowered, and the lifetime is prolonged.

Description

technical field [0001] The present invention relates to the application of Clostridium butyricum in the preparation of preparations for inducing anti-tumor immunity and immune checkpoint inhibitor sensitization, specifically, using Clostridium butyricum to prepare preparations for inducing anti-tumor immunity and immune checkpoint inhibitor sensitization, and providing the preparation The method for treating cancer with combined immune checkpoint inhibitor belongs to the field of biomedicine. Background technique [0002] Immune checkpoint blockade therapy is currently a hot spot in tumor immunotherapy, CTLA-4 (cytotoxic T lymphocyte-associated antigen), PD-1 (programmed cell death protein 1) and PD-L1 (PD-1 ligand 1) It is a relatively well-studied immune checkpoint molecule at present. Antibodies against these immune checkpoint molecules can block related signaling pathways and enhance endogenous anti-tumor immune effects. These antibody molecules are immune checkpoint inh...

Claims

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Application Information

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IPC IPC(8): A61K35/74A61P35/00A61P37/02A61P35/02A23L33/135A23L2/38
Inventor 崔云龙赵婀姿李洪福
Owner QINGDAO EASTSEA PHARMA
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