Method for extracting high-activity alpha-glucosidase inhibitor from polygonum hydropiper
A technology of glucosidase and Polygonum solani is applied in the field of natural medicinal chemistry, which can solve the problems such as the application research of Polygonum solani, which has not been seen, and achieve the effect of excellent α-glucosidase inhibitory activity.
Active Publication Date: 2019-05-21
QUANZHOU NORMAL UNIV
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Problems solved by technology
So far, there have been no public reports or patents on the application of Polygonum syringae in reducing blood sugar and lipids, or for the preparation of drugs or health products with hypoglycemic or blood lipid-lowering effects.
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Embodiment 1
[0026] Embodiment 1 A kind of method of extracting highly active α-glucosidase inhibitor from Polygonum hydroponica
[0027] (1) Preparation of Polygonum vulgaris powder: Select Polygonum vulgaris to remove impurities, dry at 60°C for 4 hours, then pulverize through a high-speed pulverizer, pass through an 80-mesh sieve, and pack into bags for later use.
[0028](2) Preparation of ethanol extract of Polygonum syringae: Weigh 5000g of Polygonum syringae powder, add 80% ethanol solution with volume concentration according to the ratio of mass volume ratio 1:10 g / ml, stir and swell fully, and extract with ultrasonic power 480w 20 minutes, then stir and extract at room temperature for 60 minutes, centrifuge at 5000r / min for 10 minutes, and take the supernatant. Repeatedly leaching 3 times according to the above method, combining the supernatants, concentrating under reduced pressure and vacuum rotary evaporation to form an extract, that is, the ethanol extract of Polygonum hydropi...
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The invention relates to the technical field of natural medicinal chemistry, in particular to a method for extracting a high-activity alpha-glucosidase inhibitor from polygonum hydropiper. The extraction method comprises the following steps: taking dried powder, crushing the powder, executing extraction with ethanol for three times, concentrating an extracting solution, and removing a solvent to obtain a polygonum hydropiper ethanol extract; adding water to suspend the polygonum hydropiper, executing multiple times of execution with petroleum ether to obtain a polygonum hydropiper petroleum ether extract, and making the polygonum hydropiper petroleum ether extract pass through a silica gel chromatographic column two times to obtain the high-activity alpha-glucosidase inhibitor extracted from polygonum hydropiper. The high-activity alpha-glucosidase inhibitor obtained by adopting the extraction method has excellent alpha-glucosidase inhibitory activity which is 122 times of the activityof a positive control drug acarbose.
Description
technical field [0001] The invention relates to the technical field of natural medicinal chemistry, in particular to a method for extracting highly active α-glucosidase inhibitors from Polygonum hydroponica. Background technique [0002] Diabetes is a metabolic disease characterized by chronic hyperglycemia caused by various etiologies. Diabetes has become a worldwide public health problem that seriously threatens human health. According to statistics from the International Diabetes Federation (IDF), approximately 425 million adults worldwide suffer from diabetes in 2017. Diabetes patients in my country have exceeded 100 million, and the adult diabetes prevalence rate is 11.6%, presenting a highly prevalent trend. [0003] Clinically, diabetes is mainly divided into type 1 and type 2, and the proportion of type 2 diabetic patients is about 90% of all diabetic patients. Clinically, chemical drugs are mainly used to treat diabetes, which has the characteristics of strong hyp...
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Login to View More IPC IPC(8): A61K36/704A61P3/10A61P3/06
Inventor 王芳陈佳慧戴聪杰董乐
Owner QUANZHOU NORMAL UNIV