Parathyroid gland intra-operative real-time detection method based on Raman spectrum technology

Abstract

The invention provides a parathyroid gland intra-operative real-time detection method based on the Raman spectrum technology, which comprises the following steps of: step 1, detecting tissues to be identified by using a Raman spectrometer to obtain spectral data; step 2, converting the spectral data into a .Txt format, carrying out fluorescence background removal, noise reduction, smoothing and normalization processing, and outputting the spectral data into a .xls format; step 3, establishing a Raman spectrum database, and importing the spectrum data in the .xls format into the man spectrum database; step 4, establishing a machine learning module, wherein the machine learning module establishes a differential diagnosis model according to the Raman spectrum database; and step 5, importing the spectral data of the tissue to be identified into the differential diagnosis model for comparison. According to the parathyroid gland intra-operative real-time detection method based on the Raman spectrum technology, parathyroid glands can be detected and recognized objectively, accurately, simply and conveniently in real time.

Description

technical field [0001] The invention relates to the medical field, in particular to a method for real-time detection of parathyroid glands during surgery based on Raman spectroscopy. Background technique [0002] The parathyroid gland is one of the most important endocrine glands in the human body. There are two pairs of parathyroid glands in the human body, which are brown and yellow in shape, and are located in the middle and lower parts of the back (or buried in) of the left and right thyroid glands. The main function is to secrete parathyroid hormone (referred to as PTH), and regulate the metabolism of calcium and phosphorus in the body. Hypoparathyroidism or complete removal (such as accidental removal of the thyroid gland during surgical resection), the insufficient secretion of PTH will gradually decrease blood calcium and gradually increase blood phosphorus, resulting in hypocalcemic convulsions and even death. Supplement PTH and Calcium salts may temporarily relie...

AI Technical Summary

Problems solved by technology

The appearance of the parathyroid glands is brownish yellow or yellow, and it is difficult to distinguish it from the surrounding adipose tissue during thyroidectomy, which often leads to miscutting. Patients are prone to serious complications such as PTH secretion disorder after operation, and long-term medication is required, resulting in economic and economic losses for patients. Great impairment of quality of life

At present, there is no objective real-time diagnostic technology to assist doctors in judging parathyroid glands during surgery, and the identification of them from adipose tissue mainly depends on the doctor's clinical experience, which is relatively subjective. A Difficulty and a Key Point to be Solved Urgently

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