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Multi-nuclear magnetic resonance radio frequency channel device for polarization transfer enhancement technology

A technology of nuclear magnetic resonance and radio frequency channels, which is applied in the direction of magnetic resonance measurement, etc., to achieve the effect of reducing the transformation cost and improving the signal-to-noise ratio

Active Publication Date: 2019-05-21
WUHAN INST OF PHYSICS & MATHEMATICS CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to overcome the deficiency that the single proton channel magnetic resonance imager cannot perform polarization transfer experiments, the present invention provides a multi-nuclear magnetic resonance radio frequency channel device for polarization transfer enhancement technology, which can be used on the basis of the proton channel magnetic resonance imager , does not change the internal structure of the original hardware system, increases the heteronuclear transmission channel through an external frequency conversion device, and can realize the proton channel to achieve transmission and reception, heteronucleus channel transmission and reception, cross transmission and reception and other working modes through the control signal sequence. function, so as to realize the polarization transfer experiment on the single proton channel magnetic resonance imager at low cost, and has the advantages of flexible adjustment and online switching

Method used

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  • Multi-nuclear magnetic resonance radio frequency channel device for polarization transfer enhancement technology
  • Multi-nuclear magnetic resonance radio frequency channel device for polarization transfer enhancement technology
  • Multi-nuclear magnetic resonance radio frequency channel device for polarization transfer enhancement technology

Examples

Experimental program
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Effect test

Embodiment 1

[0055] 1. System connection

[0056] exist figure 1 As shown, a multi-nuclear magnetic resonance radio frequency channel device for polarization transfer enhancement technology includes a proton transceiver switch 2, a heteronuclear emission channel 3, a radio frequency probe 4, an up-conversion unit 5, a receiving channel 6 and a control circuit 7.

[0057] The proton transceiver switch 2 includes a first proton transceiver switch end, a second proton transceiver switch end, and a proton transceiver fixed end.

[0058] The hetero-core transmission channel 3 includes a down-conversion module 3a, a hetero-core power amplifier 3b and a transceiver switch 3c. The transceiver switch 3c includes a first transceiver switch switching terminal, a second transceiver switch switching terminal and a transceiver switch fixed terminal.

[0059] The radio frequency probe 4 includes a probe proton channel 4a and a probe heteronucleus channel 4b.

[0060] The up-conversion unit 5 includes ...

Embodiment 2

[0096] The multi-nuclear magnetic resonance radio frequency channel device for the polarization transfer enhancement technique described in Embodiment 1 is used to perform the single proton working mode. The single proton working mode is mainly used for the acquisition of positioning images, which is the same as the original working mode of the instrument.

[0097] Before the experiment starts, the tuning and matching of the probe proton channel 4a and the probe heteronucleus channel 4b of the radio frequency probe 4 should be adjusted so that the radio frequency probe 4 achieves the minimum reflection at the corresponding frequency. Close the mode switching control signal b of the control circuit 7, that is, the mode switching control signal b is 0, and the output signal of the control circuit 7 is as follows:

[0098] The proton power amplifier control signal ① is 1, and the proton power amplifier 1a is working;

[0099] The proton transceiver switch control signal ② is the...

Embodiment 3

[0105] The multi-nuclear magnetic resonance radio frequency channel device for the polarization transfer enhancement technology described in Embodiment 1 is used to perform single-hetero-nuclear working mode. The single heteronucleus mode is used to determine the 90° pulse parameters of the heteronucleus, and can also be used for other single heteronucleus and partial heteronucleus homonuclear experiments.

[0106] Before the experiment starts, the tuning and matching of the probe proton channel 4a and the probe heteronucleus channel 4b of the radio frequency probe 4 should be adjusted so that the radio frequency probe 4 achieves the minimum reflection at the corresponding frequency.

[0107] Open the mode switching control signal b of the control circuit 7, that is, the mode switching control signal b is 1, and the output signal of the control circuit 7 is as follows:

[0108] The proton power amplifier control signal ① is 0, and the proton power amplifier 1a stops;

[0109]...

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Abstract

The invention discloses a multi-nuclear magnetic resonance radio frequency channel device for a polarization transfer enhancement technology. The device includes a radio frequency probe, a proton transceiving switch, a heteronuclear transmission channel, an up-conversion part and a receiving channel, the heteronuclear transmission channel comprises a down-conversion module, a heteronuclear power amplifier and a heteronuclear transceiving switch, wherein the radio frequency probe comprises a probe proton channel and a probe heteronuclear channel, the up-conversion part comprises a heteronuclearpre-amplifier and an up-conversion module, and the receiving channel comprises a proton pre-amplifier and a channel change-over switch. The invention reduces the improvement cost for a polarization transfer experiment of a single-proton channel magnetic resonance instrument. Through time sequence control of each module, the signal-to-noise ratio of a heteronuclear experiment can be improved by using a polarization transfer technology.

Description

technical field [0001] The invention relates to the fields of magnetic resonance spectroscopy and magnetic resonance imaging, in particular to a multi-nuclear magnetic resonance radio frequency channel device for polarization transfer enhancement technology. Background technique [0002] Polarization transfer enhancement technique is an important NMR experimental method, which is widely used in heteronuclear experiments. The gyromagnetic ratio of most heteronuclei is significantly lower than that of protons. According to Zeeman splitting and Boltzmann's law, the polarization degree of nuclear thermal equilibrium with low gyromagnetic ratio is low, and the sensitivity of direct measurement is also low. Comparison. The polarization transfer enhancement technology can transfer the proton spin to the heteronucleus through the coupling between the proton and the heteronucleus. The signal polarization obtained at this time is close to the proton thermal equilibrium polarization ...

Claims

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Application Information

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IPC IPC(8): G01R33/34
Inventor 周欣单海威石磊孙献平张许叶朝辉刘买利
Owner WUHAN INST OF PHYSICS & MATHEMATICS CHINESE ACADEMY OF SCI