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Choriocarcinoma treating cherimoya seed extract and preparation and application methods thereof
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A choriocarcinoma and extract technology, which is applied in the field of tumor treatment and biomedicine, can solve the problems of shortened survival period, decreased patient's physical fitness and resistance, etc., and achieves the effect of selectivity, action, and high-efficiency killing effect.
Active Publication Date: 2019-05-24
INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI
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However, chemotherapy drugs generally have the problem of excessive toxicity and side effects, which often lead to killing one thousand enemies and self-injury eight hundred, sharply reducing the patient's physical fitness and resistance, and greatly shortening the survival period
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preparation example Construction
[0043] The invention provides a kind of preparation method of custard apple seed extract, comprises the steps:
[0044] (1) pulverizing the custard apple seeds to obtain granules;
[0045] (2) mixing the particulate matter with a degreasingsolvent, and separating the solid and liquid after degreasing to obtain a filter residue;
[0046](3) mixing the filter residue with the extraction solvent, separating the solid and liquid after extraction to obtain a liquid phase;
[0048] In the invention, the seeds of the custard apple are first pulverized to obtain granules. In the present invention, the varieties of the custard apple seeds preferably include custard apple, soursop and / or custard apple. The crushed particle size is preferably 2-25 mesh, more preferably 10-18 mesh.
[0049] After the particle is obtained, the present invention mixes the particle with a degreasing solvent,...
[0067] Take 20 grams of dried custard apple seeds, crush them into 15-mesh particles, add n-hexane to soak and degrease twice (use 200mL of n-hexane each time, shake intermittently, for 5 hours), filter with filter paper, and add 200ml of absolute ethanol to the filter residue , 25°C and 250W ultrasonic extraction twice, each time 30min, filter paper suction filtration, combined two filtrates, 55°C heating and rotary evaporation under reduced pressure to remove the organic solvent, vacuum drying to obtain the ethanol ultrasonic extract.
Embodiment 2
[0069] Annus apple, ultrasonically extracted with ethanol (soil-alcohol ultrasonically extracted)
[0070] Take 20 grams of dried custard apple (commonly known as custard apple) seeds, crush them into 18-mesh particles, add n-hexane to soak and degrease twice (use 200mL of n-hexane each time, shake intermittently, for 5 hours), filter paper suction, and filter residue Add 200ml of absolute ethanol, ultrasonically extract twice at 25°C and 250W for 30min each time, filter with filter paper, combine the two filtrates, heat at 60°C under reduced pressure and rotary evaporate to remove the organic solvent, and dry in vacuo to obtain the ethanol ultrasonic extract.
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Abstract
The invention provides application of one or more compounds shown in a formula I, a formula II and a formula III to preparing choriocarcinoma treating drugs and belongs to the technical field of antitumor drugs. The compounds shown in the formula I, the formula II and the formula III are monomer components of a cherimoya total lactone extract. The invention also provides a preparation method of achoriocarcinoma treating cherimoya seed extract and products thereof. The compounds shown in the formula I, the formula II and the formula III and the prepared choriocarcinoma treating cherimoya seedextract (including effective parts) have an IC50 (half maximal inhibitory concentration) less than 10 ng / ml to choriocarcinoma JEG-3, wherein the prepared choriocarcinoma treating cherimoya seed extract has an IC50 as low as 1.269 mg / mL to the choriocarcinoma JEG-3; the effective parts have an IC50 of 0.4277 nM to the choriocarcinoma JEG-3; particularly, the compound shown in the formula I achievean IC50 of only 0.1302 nM to the choriocarcinoma JEG-3 but of usually 0.1-100 mu M to most other tumors, namely, three orders of magnitude exist, so that high selectivity and efficient killing effects on the choriocarcinoma JEG-3 can be achieved.
Description
technical field [0001] The invention belongs to the technical fields of tumor treatment and biomedicine, and in particular relates to an anemoneapple seed extract for treating choriocarcinoma, a preparation method and application thereof. Background technique [0002] Malignant tumor is a major disease that seriously endangers human life and health, and has become one of the main causes of death from diseases today. The incidence and mortality of cancer in my country continue to rise, and the situation is grim. At present, the main treatment methods for malignant tumors include surgery, radiotherapy and chemotherapy. Chemotherapy is still the main way to deal with tumors because the recurrence and metastasis of tumors after surgery still requires chemotherapy. Clinicians can optimize the maximum curative effect and minimum toxicity by adjusting the dosage of drugs, helping patients prolong survival time and improve the prognosis of life quality. However, chemotherapy dru...
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