An orthopedic adhesive capable of promoting bone growth and its preparation method

Abstract

The invention discloses an orthopedic adhesive with the function of promoting bone growth and a preparation method thereof. The adhesive comprises the following raw materials in parts by weight: 40-60 parts of modified magnesium phosphate bone cement, 10-20 parts of nano-calcium carbonate 10-20 parts of sodium alginate, 1-3 parts of sodium selenite, 3-5 parts of pearl powder, 3-5 parts of medical stone, 5-10 parts of sodium polyacrylate, 1-3 parts of calcium lignosulfonate 1-3 parts of glycerin, 3-5 parts of chitosan, 3-5 parts of lecithin, 1-3 parts of Sapinberry saponin, 5-10 parts of gum arabic and 10-15 parts of collagen. The adhesive provided by the invention has the advantages of good cohesiveness, no side effects, good biocompatibility, good antibacterial properties, can promote callus growth, accelerate fracture healing, and has good water solubility, etc., and can meet clinical application requirements , suitable for orthopedics, spine surgery, osteoporosis treatment and fracture fixation and treatment.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to an orthopedic adhesive capable of promoting bone growth and a preparation method thereof. Background technique [0002] Humans have a long history of applying medical adhesive materials. In recent decades, in order to reduce the complexity of surgery, medical adhesives have been developed rapidly and widely used. In surgical operations, medical adhesives are used for local bonding and repair of certain organs and tissues, and to prevent bleeding from capillaries at sutures after surgery; in gynecology, it is used to block the fallopian tubes to complete ligation; in dentistry, it is used for tooth repair; orthopedic surgery The combination and positioning of bones and joints. Adhesives for bone require good biocompatibility. Degradability, no visceral toxicity and cytotoxicity, no carcinogenic and teratogenic effects, and rapid adhesion can be achieved under normal te...

AI Technical Summary

Problems solved by technology

However, there are disadvantages such as high brittleness, poor water solubility (blood solubility), insufficient mechanical properties, and slow degradation, which limit its wide application in clinical practice, and composite bone cement will help improve its performance.

[0005] Currently commonly used adhesive materials have their own advantages and disadvantages. Although chemical adhesive materials have strong adhesive force, they are extremely difficult to absorb in the body and often have certain toxic and side effects; protein adhesive materials may cause strong allergic and immune reactions. Or infected with viruses, the adhesive force is too small to bond and fix bone blocks, and it is difficult for a single material to meet the needs of bone tissue repair for the complex structure of bone tissue

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