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Crosslinking method with photochemical tissue adhesion

A technology of adhesion and cross-linking method, which is applied in the field of medical supplies, can solve the problems of lack of dyeing substance carriers and unclear dyeing techniques, and achieve the effects of avoiding poor wound healing, less inflammation, and shorter time consumption

Inactive Publication Date: 2019-05-31
JIAXING KS MEDICAL EQUIP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing photochemical tissue adhesion technology has problems such as lack of dyeing substance carrier and unclear dyeing technology, which need to be solved urgently.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] This embodiment provides a cross-linking method with photochemical tissue adhesion. The method is to use the biological amnion as a carrier, dye the biological amnion with a photosensitizer and cover it on the tissue to be bonded, and perform photochemical bonding under the excitation of green light. tissue adhesion.

[0027] The photosensitizer is rose bengal solution.

[0028] The mass concentration of the rose bengal solution is 0.05-0.09% (w / v).

[0029] The preparation method of the rose bengal solution is as follows: dissolving the rose bengal powder in sterile PBS.

[0030] In the biological amnion staining photosensitizer, the staining time is 2 minutes.

[0031] The wavelength of the green light source is 532nm, and the irradiation integrated flux is 100-200J / cm 2 .

[0032] The green light irradiation time is 1 to 30 minutes, and the light energy is 0.1 to 0.4 W / cm 2 , the spot area is 0.7~1.2cm 2 .

[0033] Effect verification:

[0034] The method d...

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Abstract

The invention provides a crosslinking method with photochemical tissue adhesion. The method includes using biological amnion as a carrier, dyeing the biological amnion with a photosensitizer, coveringthe tissue to be bonded with the biological amnion, and conducting photochemical tissue bonding under the excitation of green light. The performance of the amnion dyed with RB to generate the photochemical tissue bonding under the excitation of the green light is utilized, the use of sutures can be avoided to obtain less inflammation, fibrosis and scars, and the wound can be watertight rapidly. The technique is suitable for microsurgery and fine tissues difficult to suture, and especially provides a new approach for tissue suture-free adhesion in an ophthalmic surgery.

Description

technical field [0001] The invention relates to the technical field of medical supplies, in particular to a cross-linking method with photochemical tissue adhesion, and also relates to the application of the cross-linking technology with photochemical tissue adhesion in various ophthalmic operations that require the participation of amniotic membrane. Background technique [0002] Amniotic membrane has been widely used in clinical operations, but conventional suturing brings many disadvantages. Biological amniotic membrane is rich in collagen fibers, and amniotic membrane has been widely used clinically in the field of ophthalmology, including various corneal epithelial repairs, pterygium amniotic membrane transplantation, ocular surface reconstruction, glaucoma filtration, scleral laceration or eyeball rupture repair , corneal transplantation, prosthetic eye seat implantation and other operations. [0003] However, currently, in ophthalmic surgery using bio-amniotic membra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/00
Inventor 朱鸿黄海清冯竞仰胡洁
Owner JIAXING KS MEDICAL EQUIP CO LTD
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