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Intelligent child testis prosthesis based on implanted silica gel

A testicular prosthesis, children's technology, applied in the field of prosthesis, can solve problems such as infection, achieve the effect of improving hydrophilicity, reducing hydrophobicity, and improving binding ability

Active Publication Date: 2019-05-31
THE SECOND HOSPITAL AFFILIATED TO WENZHOU MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Early testicular prostheses used alloys, ceramics, and organic plastics as prosthetic materials. Due to their defects in texture, weight, toxicity, and tissue compatibility, they have been gradually eliminated. Silicone rubber is now commonly used as testicular prostheses in clinical practice. The material of the body; testicular prosthesis implantation has been clinically used for decades, but like other implantation operations, complications such as infection are likely to occur after surgery, and the testicular prosthesis stays in the human body for a long time. This requires the testicular prosthesis to have strong antibacterial properties, and at the same time, the antibacterial performance lasts for a long time, but there is no such testicular prosthesis on the market so far

Method used

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  • Intelligent child testis prosthesis based on implanted silica gel
  • Intelligent child testis prosthesis based on implanted silica gel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] The synthesis of antibacterial agent comprises the following steps:

[0036] Step 1: Stir and disperse 20g Na-montmorillonite in 200ml distilled water, then add 80g mass fraction of 10% zinc nitrate aqueous solution (wherein the quality of zinc nitrate is 8g), stir and mix for the first time, and the stirring temperature is set to 70°C, the stirring time is 8h, the stirring speed is 600r / min, after the stirring is completed, filter to obtain the precipitate; wash with deionized water, filter, dry in an oven at 80°C for 48h, and pass through a 300-mesh sieve to obtain zinc-loaded Montmorillonite;

[0037] Step 2: Stir and disperse the zinc-loaded montmorillonite prepared in step 1 in 200ml of distilled water, then add 100ml of absolute ethanol, 4g of propenyl propyl disulfide, 1g of [(3'S)-1'-tert-butoxy Carbonyl-2-oxo[1,3'-bipyrrolidinyl]-3-yl]triphenylphosphonium bromide and 5g allyltriphenylphosphonium chloride were stirred and mixed for the second time, and the stir...

Embodiment 2

[0039] An intelligent children's testicular prosthesis based on implantable silica gel is characterized in that: it comprises a shell, an inner core and an injection layer, and the injection layer is positioned between the shell and the inner core; the injection layer is used for injecting physiological saline, and the The inner core is made of silicone gel; the outer shell is made of antibacterial silicone rubber;

[0040] The antibacterial silicone rubber comprises the following components by weight:

[0041] 80 parts of silicone rubber;

[0042] 4 parts of coupling agent;

[0043] 5 parts of cross-linking agent;

[0044] 8 parts of modifier;

[0045] 4 parts of stabilizer;

[0046] Antibacterial agent 2 parts.

[0047] The modifying agent is a mixture of N-tris(hydroxymethyl)methyl-3-aminopropanesulfonic acid, octadecyltrimethylammonium bromide and 2-amino-5-bromopyridine-4-carboxylic acid , its mass ratio is 4:1:2;

[0048] The coupling agent is 3-(2-aminoethylamine) ...

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Abstract

The invention discloses an intelligent child testis prosthesis based on implanted silica gel, which comprises a shell, an inner core and an injection layer, wherein the injection layer is positioned between the shell and the inner core, the injection layer is used for injecting physiological saline, the inner core is made of silica gel, and the shell is made of antibacterial silicon rubber. The antibacterial silicon rubber comprises the following substances in parts by weight:80 parts of silicon rubber,4 parts of coupling agents,5 parts of cross-linking agents,8 parts of modifiers,4 parts of stabilizers and 2 parts of antibacterial agents.The modifiers are mixtures of N-Tris (hydroxymethyl) methyl-3-aminopropanesulfonic acid, octadecyltrimethyl ammonium bromide and 2-amino-5-bromopyridine-4-carboxylic acids. The stabilizers aremixtures of lauryl polyoxyethylene ether ammonium sulfate, diethylene glycol mono[(1,1,3,3-tetramethylbutyl) phenyl] ether and 4-benzoyl-3-methyl-1-phenyl-2-pyrazole-5-one. After the antibacterial silicone rubber is made into the testis prosthesis, the testis prosthesis also has strong antibacterial property and long antibacterial time; and meanwhile, the antibacterial silicone rubber has good biocompatibility and is non-toxic and harmless.

Description

technical field [0001] The invention relates to a prosthesis, in particular to an intelligent children's testicular prosthesis based on implantable silica gel. Background technique [0002] Absence of testicles and orchidectomy are not only the loss of physical organs, but also psychological defects for patients. Many patients will choose or hope to make up for this physical loss by choosing exogenous testicular substitutes-testicular prosthesis. Physical and psychological loss; the commonly used testicular prosthesis treatment in clinical practice is only a plastic replacement of male gonads in appearance, without the physiological function of testes (endocrine and spermatogenesis), but it has a psychological impact on patients. The effect on health is irreplaceable by androgen therapy. [0003] Testicular prosthesis is an artificial product similar to testis in appearance. It has experienced a process from inorganic materials to organic compounds, and from low molecular m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/54A61L27/02A61L27/00A61L27/50A61L27/18A61F2/02
Inventor 林孝坤陈聪德邵方滨王永飚林杰夏立广张华刘平
Owner THE SECOND HOSPITAL AFFILIATED TO WENZHOU MEDICAL COLLEGE
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