A kind of hypromellose enteric-coated empty capsule with potassium salt and sodium salt gel

A technology of hypromellose and hollow capsules is applied in the directions of capsule delivery, medical preparations with non-active ingredients, pharmaceutical formulations, etc. The effect of low water volume and high medication compliance

Active Publication Date: 2021-02-26
CHONGQING HENGSHENG MEDICINAL CAPSULE
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, after several years of production and use practice, it is found that when the patented method is used to produce hollow capsules, the proportion of microbubbles and uneven thickness on the capsule body is too large, and often about 30% of the products are unqualified, resulting in low production efficiency.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of hypromellose enteric-coated empty capsule with potassium salt and sodium salt gel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023](1) Take 50 kg of hypromellose and put it into 120L of purified water at a temperature of 85°C, stir and mix quickly for 13 minutes, and then keep it at a temperature of 82°C for 60 minutes to obtain a hypromellose solution.

[0024](2) Take 270g of gellan gum and stir and swell it in 120L of purified water at a temperature of 40°C, then heat to 85°C and keep it at rest for 55 minutes to obtain a gellan gum swelling liquid.

[0025]⑶ The gellan gum swelling liquid was added to the hypromellose solution at a temperature 3°C higher than the temperature of the hypromellose solution. When adding, the hypromellose solution and the gellan gum swelling liquid were added to the same Pour into the mixing kettle at the same speed and start stirring when pouring. After pouring, continue to stir and mix for 13 minutes, and then cool to 75°C to obtain a hypromellose gel solution.

[0026]⑷ Take 270g of potassium chloride and add it to the hypromellose gel solution, stir at 900 rpm for 2 minutes, th...

Embodiment 2

[0035](1) Take 50 kg of hypromellose and put it into 125L of purified water at a temperature of 92°C, stir and mix quickly for 15 minutes, and then keep it at a temperature of 85°C and let it stand for 75 minutes to obtain a hypromellose solution.

[0036](2) Take 357g of gellan gum, stir and swell it in 125L of purified water at a temperature of 42.5°C, then heat to 90°C and keep it at rest for 60 minutes to obtain a gellan gum swelling liquid.

[0037]⑶ The gellan gum swelling liquid was added to the hypromellose solution at a temperature 4°C higher than the temperature of the hypromellose solution, and the hypromellose solution and the gellan gum swelling liquid were added to the same Pour into the mixing tank at the same speed and start stirring when pouring. After pouring, continue to stir and mix for 15 minutes, and then cool to 80°C to obtain a hypromellose gel solution.

[0038]⑷ Add 286 g of potassium chloride to the hypromellose gel solution, stir for 2.5 min at 1000 rpm, then vacu...

Embodiment 3

[0046](1) Take 50 kg of hypromellose and put it into 130L of purified water at a temperature of 98°C, stir and mix quickly for 17 minutes, and then keep it at a temperature of 92°C for 90 minutes to obtain a hypromellose solution.

[0047](2) Take 405g of gellan gum and stir and swell it in 130L of purified water at a temperature of 45°C, then heat to 95°C and keep it for 65 minutes to obtain a gellan gum swelling liquid.

[0048]⑶ The gellan gum swelling liquid is added to the hypromellose solution at a temperature 5°C higher than the temperature of the hypromellose solution, and the hypromellose solution and the gellan gum swelling liquid are added to the same Pour into the mixing kettle at the same speed and start stirring when pouring. After pouring, continue to stir and mix for 17 minutes, and then cool to 85°C to obtain a hypromellose gel solution.

[0049]⑷ Add 310 g of potassium chloride to the hypromellose gel solution, stir at 1100 rpm for 3 minutes, then vacuum and degas for 11 mi...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a hypromellose enteric-coated hollow capsule with potassium salt and sodium salt gel, which belongs to the technical field of hollow capsule production. Firstly, the hypromellose is stirred into purified water to form a hypromellose solution, and then mixed into the gelatinized Glue to obtain hypromellose colloidal solution, then mixed with potassium salt to obtain hypromellose potassium gel solution, then mixed with sodium salt to obtain hypromellose colloidal solution, and then dipped in glue to make hypromellose sausage Dissolving hollow capsules; the beneficial effect is that the addition of sodium alginate improves the moldability of the colloidal solution, and the solution is first mixed with potassium salt and then sodium alginate, which can greatly reduce the problem of uneven thickness when dipping in the gel; The gel swelling solution is mixed when the temperature of the hypromellose solution is higher than that of the hypromellose solution. Combined with vacuum filtration and degassing, the residual fine air bubbles in the solution can be completely released, basically eliminating the fine air bubbles on the hollow capsule body, and effectively improving Product quality, improve production efficiency.

Description

Technical field[0001]The invention belongs to the technical field of hollow capsule production, in particular to a plant-based enteric hollow capsule prepared by using hypromellose as a raw material and gelled with potassium salt and sodium salt.Background technique[0002]The hollow capsule is composed of a cap and a body two capsule shells refined from medicinal materials, which are used to contain solid medicines; such as self-made powders, health care products, medicines, etc., which solve the problem of difficult intake and poor taste for users, and truly realize The good medicine is no longer bitter; because hollow capsules are easy to swallow, they can effectively cover up the uncomfortable taste and smell of the contents, and they are becoming more and more popular with patients.[0003]The previous hollow capsules mainly include animal gelatin capsules and various vegetable capsules. In view of the various defects of the existing capsules, the company developed and applied for ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K47/38A61K47/36
Inventor 吴易果李全忠华玉容唐杰胡晓涛
Owner CHONGQING HENGSHENG MEDICINAL CAPSULE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap