Application of two long-chain non-coding RNAs in blood for combined diagnosis of esophageal squamous cell carcinoma

A long-chain non-coding, cellular cancer technology, applied in the field of joint diagnosis of esophageal squamous cell carcinoma with two long-chain non-coding RNAs in the blood, to achieve good diagnostic results, reduce patient pain, and save medical resources

Pending Publication Date: 2019-06-25
江苏万成生物医学研究院有限公司
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Problems solved by technology

[0004] At present, ESCC does not have plasma tumor markers t

Method used

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  • Application of two long-chain non-coding RNAs in blood for combined diagnosis of esophageal squamous cell carcinoma
  • Application of two long-chain non-coding RNAs in blood for combined diagnosis of esophageal squamous cell carcinoma
  • Application of two long-chain non-coding RNAs in blood for combined diagnosis of esophageal squamous cell carcinoma

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Embodiment Construction

[0027] The present invention will be further explained below in conjunction with the accompanying drawings and specific embodiments. It should be understood that the following specific embodiments are only used to illustrate the present invention and are not intended to limit the scope of the present invention.

[0028] Such as Figure 1 to Figure 7 As shown, the present invention discloses the application of two long-chain non-coding RNAs in the combined diagnosis of esophageal squamous cell carcinoma. The nucleotide sequence of the lnc_XR_242314.2 molecular marker is SEQ ID NO.1, and the nucleotide sequence of the lnc_TCONS_00011689 molecular marker The nucleotide sequence is SEQ ID NO.2.

[0029] 1. Research materials

[0030] 1.1 Subjects of the experiment.

[0031] This study is based on the Department of Oncology, Nanjing Hospital Affiliated to Nanjing Medical University. The Department of Oncology treats patients with esophageal squamous cell carcinoma all the year ro...

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Abstract

The invention discloses an application of lnc_XR_242314.2 and lnc_TCONS_00011689 in blood for combined diagnosis of esophageal squamous cell carcinoma. The nucleotide sequence of an lnc_XR_242314.2 molecular marker is SEQ ID NO. 1, and the nucleotide sequence of an lnc_TCONS_00011689 molecular marker is SEQ ID NO. 2. The discovery, detection, and application of lnc_XR_242314.2 and lnc_TCONS_00011689 are related, and a specific detection primer for real-time quantitative PCR can be designed and synthesized. The lnc_XR_242314.2 and lnc_TCONS_00011689 in the blood can be used as plasma markers for ESCC patients, and the combination effect is better. The above method of examination is easily accepted by a subject and can be an effective means of early diagnosis, determination of disease progression and prognosis assessment of the ESCC patients.

Description

technical field [0001] The invention relates to the field of tumor molecular biology, in particular to an application in combined diagnosis of two long-chain non-coding RNAs in blood for squamous cell carcinoma of the esophagus. Background technique [0002] Esophageal carcinoma (esphaogeal carcinoma, EC) is one of the most common malignant tumors that seriously threaten human health. There are two main pathological types: squamous cell carcinoma and adenocarcinoma. Clinically, 90% of esophageal cancer is squamous cell carcinoma (esophageal squamous cell carcinoma, ESCC), and its distribution has obvious regional differences. The incidence of ESCC in my country accounts for more than 70% of the world, and its prognosis is poor. The 5-year overall survival rate is only 15%-25%. The poor prognosis of esophageal cancer is related to the middle and advanced stage when it is discovered, and some patients even have superficial primary tumors but have already metastasized distantl...

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Application Information

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IPC IPC(8): C12Q1/6886C12N15/113
Inventor 康宁朱桂芳曹秀峰
Owner 江苏万成生物医学研究院有限公司
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