Pyrazole amide compound and application thereof and bactericide

A technology of pyrazole amide and compound is applied in the field of pesticides and fungicides, which can solve the problems of poor control effect and soybean rust control effect, and achieve good control effect.

Active Publication Date: 2019-07-02
HUAZHONG NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] The purpose of the present invention is to overcome the poor control effect of the pyrazole amide compound of diphenyl ether provided by the prior art on soybean rust, corn rust, wheat powdery mildew and cucumber powdery mildew or the control effect on soybean rust at low concentration Poor defect, providing a new class of pyrazole amides with excellent efficacy against soybean rust, corn rust, wheat powdery mildew and cucumber powdery mildew even at low concentrations

Method used

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  • Pyrazole amide compound and application thereof and bactericide
  • Pyrazole amide compound and application thereof and bactericide
  • Pyrazole amide compound and application thereof and bactericide

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Embodiment 1

[0038] The pyrazole amide compound (that is, the following compound 1) of the structure shown in formula (1) is prepared by using the synthetic route described above in the present invention, specifically as follows:

[0039] (1) Preparation of compounds shown in 1-3

[0040] Add 3mmol of the compound shown in 1-2, 3.3mmol of the compound shown in 1-1 and 3.6mmol of potassium carbonate into a 50mL round bottom flask, then add 20mL of DMF, raise the temperature to 100°C, and monitor the completion of the reaction of the raw materials by TLC After stopping the reaction, 50 mL of ethyl acetate was added, washed twice with 50 mL of saturated brine, and then dried with anhydrous sodium sulfate. After removing the solvent under reduced pressure, the intermediate 1-3 was obtained by column chromatography with a yield of 65%.

[0041] brown liquid, 1 H NMR(600MHz,DMSO)δ8.07(s,1H),7.68(d,J=8.6Hz,1H),7.05–7.00(m,1H),6.88(dd,J=8.1,1.6Hz,2H) ,6.77(d,J=8.7Hz,1H),6.62–6.58(m,1H),5.03(s,2H...

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Abstract

The invention relates to the field of pesticides, and discloses a pyrazole amide compound and application thereof and a bactericide. The pyrazole amide compound has a structure as shown in the formula(1). The pyrazole amide compound provided by the invention has a remarkable control effect on soybean rust, corn rust, wheat powdery mildew and powdery mildew of cucumber.

Description

technical field [0001] The invention relates to the field of pesticide fungicides, in particular to a pyrazole amide compound and its application, and a fungicide containing the pyrazole amide compound. Background technique [0002] Fungicides targeting succinate dehydrogenase (SDH, succinate dehydrogenase) are currently the most important type of fungicides. This type of fungicides inhibits the activity of pathogenic bacteria succinate dehydrogenase, causing the death of pathogenic bacteria and achieving for the purpose of disease control. [0003] Since this type of fungicide has a novel mechanism of action and has no cross-resistance with most fungicides currently on the market, it has become a research hotspot for major pesticide companies in the world. [0004] Among these fungicides, pyrazole amide compounds are the most numerous species on the market. Due to their wide bactericidal spectrum and high activity, they can prevent and control a variety of crop diseases in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D231/14A01N43/56A01P3/00
CPCC07D231/14A01N43/56
Inventor 杨光富李华
Owner HUAZHONG NORMAL UNIV
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