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Method and system for sorting assembly sequences

A sequence sorting and sequence technology, applied in the field of assembly sequence sorting, can solve problems such as inaccurate data sorting, and achieve the effect of improving clustering accuracy and reducing errors

Active Publication Date: 2019-07-16
武汉希望组生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] In view of the above problems, the present invention provides a method and system for sorting assembly sequences, which solves the problem of inaccurate data sorting in the prior art

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  • Method and system for sorting assembly sequences

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Embodiment Construction

[0051] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0052]The terms "first" and "second" in the specification and claims of the present invention and the above drawings are used to distinguish different objects, rather than to describe a specific order. Furthermore, the terms "comprising" and "having", and any variations thereof, are intended to cover a non-exclusive inclusion. For example, a process, method, system, product or apparatus comprising a series of steps or units is not defined by listed steps or un...

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Abstract

The invention discloses a method and system for sorting assembly sequences, and the method comprises the steps: carrying out the segmentation of a target overlapped group after the assembly of DNA sequencing fragments, and obtaining the target data; performing orientation and sorting processing on the target data to obtain a plurality of arrangement results; calculating the dispersion degree of the cross-linked signal value of each arrangement result, and performing calculating to obtain the mounting rate of a segmentation sequence in the target data, the segmentation sequence representing a sequence obtained by segmenting the overlapped group according to a preset segmentation length; determining an initial arrangement result according to the dispersion degree and the mounting rate; and performing interaction heat map verification on the initial arrangement resul; if a preset verification condition is met, determining the initial arrangement result as a target arrangement result, andif not, adjusting the initial arrangement result to obtain a target arrangement result. According to the method and the system, the problem of inaccurate sorting in the prior art is solved, and errorcorrection can be carried out on overlapped groups with obvious assembly errors.

Description

[0001] This application claims the priority of the Chinese patent application with the application number 201910160446.3 and the title of the invention "A method and system for sequencing assembled sequences" submitted to the China Patent Office on March 4, 2019, the entire contents of which are incorporated by reference In this application. technical field [0002] The invention relates to the technical field of biological information, in particular to a method and system for sorting assembled sequences. Background technique [0003] DNA is the main carrier of genetic information of organisms, and high-quality genome reference sequence is an important basis for modern biological sciences such as modern genetics and molecular biology. Therefore, gene sequencing is of great significance for basic biological science research such as exploring and understanding the essence of life, for the prevention and treatment of important human genetic diseases, and for applied research su...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06N3/12G06K9/62
CPCG06N3/123G06F18/23
Inventor 李净净易嘉成胡江汪德鹏
Owner 武汉希望组生物科技有限公司