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Antimicrobial composition

A composition and compound technology, applied in biocides, animal repellents, plant growth regulators, etc., can solve the problem of insensitivity of antimicrobial compounds to reduce the risk of microbial resistance development by substitutes

Active Publication Date: 2019-07-16
FIRMENICH SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Without wishing to be bound by any particular theory, the availability of alternatives reduces the risk of development of microbial resistance and / or insensitivity to specific antimicrobial compounds

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0169] Measurement of antimicrobial activity of compositions according to the invention

[0170] Methods for Assessing Antimicrobial Activity

[0171] The following method allows a combined assessment of the antimicrobial activity of different raw materials. The fractional inhibitory concentration index (FIC index) is a measure of activity (Garcia L.S., Clinical Microbiology Procedures Handbook, pg.140-162, 3 rd Edition(2010), ASM Press, Washington DC), and calculated according to the following formula:

[0172]

[0173] Of which (MIC A alone) and (MIC B Alone) is the minimum inhibitory concentration (MIC) when components A and B are used alone; and (MIC A combination) and (MIC B Combination) is the minimum inhibitory concentration of materials A and B when tested in combination. Component A corresponds to non-2,6-dien-1-ol and component B represents 3-neopentylpyridine, 2-methylhexan-3-one oxime, terpineol or 2-isopropyl-5- methyl phenol.

[0174] The minimum ...

Embodiment 2

[0221] ANTIMICROBIAL EFFECT IN LIQUID SOAP BASE OF COMPOSITIONS ACCORDING TO SOME FORMS PROVIDED HEREIN

[0222] Preparation of bacterial solution

[0223] Bacterial solutions of two strains of Escherichia coli DSMZ 1103 and Staphylococcus aureus DSMZ 1104 were prepared for the BCT test as follows. The stock culture stored at -80°C was subcultured on Tryptic Soy Agar (TSA) agar plate medium and incubated at 37°C for 24 hours to obtain single colonies. Single colonies of primary cultures were streaked onto TSA slants and incubated in a 37°C incubator for 24 hours. Collect the bacterial plateau of the slant culture in PBS buffer to prepare a target level of 1-5 x 10 8 CFU / mL of the suspension. A 1:100 dilution of each cell suspension in PBS buffer was used as the bacterial solution for the BCT test.

[0224] Preparation of test samples

[0225] Test samples of bases with synergistic binary mixtures were prepared as follows. The raw materials of the synergistic binary...

Embodiment 3

[0243] Antimicrobial effect of compositions according to some forms provided herein in roll-on deodorant bases

[0244] Preparation of bacterial solution

[0245]Bacterial solutions of dry C. xerosis ATCC 373 strain were prepared for BCT testing as follows. The stock culture stored at -80°C was subcultured on tryptic soybean agar medium containing 0.5% Tween 80 (TSA-TW80), and incubated at 37°C for 48 hours. The primary culture was subcultured again onto TSA-TW80 to prepare a secondary culture. A single colony of the secondary culture was inoculated into 30 ml of Brain Heart Infusion (BHI) Broth (BHI-TW80) containing 0.5% Tween 80 and incubated at 37° C. at 180 rpm for 24 hours. An aliquot (1 ml) of the 24 hr culture was inoculated into 30 ml of fresh BHI-TW80 broth and incubated at 37°C at 180 rpm for 48 hrs. Aliquots (2-3 ml) of the 48-hour culture were inoculated into four 50-ml fresh BHI-TW80 broth media and incubated at 37°C at 180 rpm for 4-6 hours. When the OD r...

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PUM

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Abstract

The present disclosure relates to the field of antimicrobial compositions. More particularly, it concerns the use of a composition as an antimicrobial agent, the composition comprising ingredients selected from the group consisting of: (i) nona-2,6-dien-l-ol in combination with at least one ingredient selected from the group consisting of 3-neopentylpyridine, 2-methylhexan-3-one oxime, terpineol and 2-isopropyl-5-methylphenol; (ii) gamma-dodecalactone in combination with at least one ingredient selected from the group consisting of 1-Methyl-4-(l-methylethenyl)-cyclohexene, 4-Methoxybenzaldehyde, and 1,3-Benzodioxole-5-carbaldehyde; (iii) (Z)-3,7-Dimethyl-2,6-octadien-l-ol and gamma-dodecalactone; (iv) cis-4(Isopropyl)cyclohexanemethanol and 4-Methoxybenzaldehyde; and (v) 1,3-Benzodioxole-5-carbaldehyde and 4-Methoxybenzaldehyde, wherein the ingredients are present in an amount sufficient to provide an antimicrobial effect. The composition and its use for the preparation of antimicrobially active perfuming compositions and consumer products are also objects of the disclosure.

Description

[0001] Cross reference to related applications [0002] This application claims priority to U.S. Provisional Patent Application Serial No. 62 / 371,462, filed August 5, 2016, and European Patent Application Serial No. 16186681.9, filed August 31, 2016, the entire contents of which are incorporated herein by reference. technical field [0003] The present disclosure relates to the field of antimicrobial compositions and their use as antimicrobial agents, or their use in the preparation of antimicrobially active perfuming compositions and consumer products. More specifically, the present disclosure relates to compositions selected from the group consisting of: (i) non-2,6-dien-1-ol in combination with 3-neopentylpyridine, 2-methyl At least one component selected from the group consisting of hexan-3-ketoxime, terpineol and 2-isopropyl-5-methylphenol; (ii) γ-laurolactone and 1-methyl -At least one selected from the group consisting of 4-(1-methylvinyl)-cyclohexene, 4-methoxybenzald...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N31/02A01N43/08A01N35/04A01N27/00A01N31/04A01N31/08A01N35/10A01N43/30A01N43/40A61K8/31A61K8/34A61K8/35A61K8/41A61K8/49A61L2/18
CPCA01N31/02A01N43/08A01N35/04A01N27/00A01N31/04A01N31/08A01N35/10A01N43/30A01N43/40A61K8/31A61K8/34A61K8/345A61K8/342A61K8/347A61K8/35A61K8/40A61K8/41A61K8/4926A61K8/4973A61Q17/005A61L9/01A61K8/33A61Q19/10A61K8/49A61K2800/56A61K2800/77A61Q13/00
Inventor M·班德拉N·奥利利G·马尔
Owner FIRMENICH SA
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