Anti-drip type povidone iodine disinfecting infusion agent and preparation method and application thereof
A povidone-iodine, anti-drip type technology is applied in the directions of topical antibacterial agents, synthetic active ingredients of polymeric materials, antibacterial drugs, etc. Hanging on the skin and other problems, to achieve the effect of good adhesion and stable iodine content
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[0037] On the other hand, the embodiment of the present invention provides a kind of preparation method of anti-drip povidone-iodine disinfectant infusion, comprising the following steps:
[0038] Add the thickener into water to dissolve, and make solution A;
[0039] Add povidone K30 into water to dissolve, add povidone iodine after dissolving, stir, dissolve, adjust pH to 4.5-5.5, and make solution B;
[0040] Add solution A to solution B in a stirring state, stir, dissolve, and make solution C;
[0041] Potassium iodate and pH stabilizer are added into water to dissolve, and after dissolving, they are added to solution C in a stirring state, stirred and dissolved to form solution D;
[0042] Weigh the surfactant, add it to dissolve in water, and add it into the stirred solution D after dissolving to form solution E;
[0043] Weigh the emulsifier, add it to the co-solvent for emulsification, and after emulsification is uniform, add it to the stirred solution E to form solu...
Embodiment 1
[0057] 1. Take 4g of xanthan gum and add it to about 300ml of water at 80-90℃, stir quickly until it is completely dissolved, cool to room temperature, and make solution A;
[0058] 2. Take 3g of povidone K30, add it to about 250ml of water, and stir until it dissolves;
[0059] 3. Accurately weigh 11g of povidone-iodine, add it to the above-mentioned 2-step solution, and stir to fully dissolve;
[0060] 4. Use 1mol / L sodium hydroxide solution to adjust the pH value of the 3-step solution to about 5.5, and make solution B;
[0061] 5. Add solution A to rapidly stirred solution B, stir well, dissolve, and make solution C;
[0062] 6. Weigh 0.5g of potassium iodate, 4g of sodium dihydrogen phosphate, and 0.7g of disodium hydrogen phosphate, and dissolve them with an appropriate amount of water. After dissolving, the solution is about 50ml, and then add it to the rapidly stirring solution C, fully stir to dissolve, and make Solution D;
[0063] 7. Take 0.15g of sodium laureth ...
Embodiment 2
[0067] 1. Take 4g of xanthan gum and add it to about 300ml of water at 80-90°C, stir quickly until it is completely dissolved, cool to room temperature, and make solution A.
[0068] 2. Take 3g of povidone K30, add it to an appropriate amount of about 250ml of purified water, and stir until it dissolves;
[0069] 3. Accurately weigh 11g of povidone-iodine, add it to the above-mentioned 2-step solution, and stir to fully dissolve.
[0070] 4. Use 1mol / L sodium hydroxide solution to adjust the pH value of the solution in step 3 to about 5.5, and make solution B.
[0071] 5. Add solution A to rapidly stirred solution B, stir well, dissolve, and make solution C.
[0072] 6. Weigh 0.5g of potassium iodate, 4g of sodium dihydrogen phosphate, and 0.7g of disodium hydrogen phosphate, dissolve it with an appropriate amount of purified water, about 50ml, then add it to the rapidly stirring solution C, fully stir and dissolve, and make solution D .
[0073] 7. Take 0.2g of sodium laur...
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