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Application of gelidium polyphenol extract serving as alpha-glucosidase inhibitor

A technology of glucosidase and lily, applied in food extraction, application, food science and other directions, can solve the problems of residue waste, insufficient research on the application of seaweed polyphenols, low comprehensive utilization efficiency, etc., and achieves easy industrialization, lily Abundant resources, good inhibitory effect

Inactive Publication Date: 2019-07-26
BEIBU GULF UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Our country is rich in resources of agarose cauliflower, and a large amount of agarose cauliflower residues will be produced in the process of processing agar. In addition to a large amount of cellulose and pentose sugars, the residues are also rich in polyphenols. Most of the residues have been wasted or used as fish feed. , the comprehensive utilization efficiency is very low
[0004] Studies have found that the reported seaweed polyphenols are similar in structure to terrestrial plant polyphenols, and their biological activity is better than that of terrestrial plants. However, the application of seaweed polyphenols in enzyme inhibitors is not deep enough.

Method used

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  • Application of gelidium polyphenol extract serving as alpha-glucosidase inhibitor
  • Application of gelidium polyphenol extract serving as alpha-glucosidase inhibitor
  • Application of gelidium polyphenol extract serving as alpha-glucosidase inhibitor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Weigh 3.0000g of agaricus powder and the same amount of 200-300 mesh silica gel, mix them evenly, put them in the kettle of ASI supercritical extractor, and carry out CO 2 Supercritical extraction, the extraction pressure is 15MPa, the extraction temperature is 50°C, 75% ethanol is used as the entrainer, the flow rate of the entrainer is 1.0mL / min, and the extraction time is 1.5h, the crude extract of polyphenols of Geliflower is obtained; the experiment is repeated three times, Taking the average value of the results, the extraction rate of polyphenols from Geliflower was 0.3mg / g (calculated by gallic acid equivalent).

Embodiment 2

[0026] Weigh 3.0000g of agaricus powder and the same amount of 200-300 mesh silica gel, mix them evenly, put them in the kettle of ASI supercritical extractor, and carry out CO 2 Supercritical extraction, the extraction pressure is 20MPa, the extraction temperature is 50°C, 75% ethanol is used as the entrainer, the flow rate of the entrainer is 1.5mL / min, and the extraction time is 2h, the crude extract of polyphenols of Geliflower is obtained; the experiment is repeated three times, and The average value of the results obtained the polyphenol extraction rate of Glycyrrhizae 0.81mg / g (in terms of gallic acid equivalent).

Embodiment 3

[0028] Weigh 3.0000g of agaricus powder and the same amount of 200-300 mesh silica gel, mix them evenly, put them in the kettle of ASI supercritical extractor, and carry out CO 2 Supercritical extraction, the extraction pressure is 25MPa, the extraction temperature is 50°C, 75% ethanol is used as the entrainer, the flow rate of the entrainer is 1.25mL / min, and the extraction time is 2.5h, the crude extract of Agaricus polyphenols is obtained; the experiment is repeated three times, Taking the average value of the results, the extraction rate of polyphenols from Geliflower was 0.72 mg / g (calculated by gallic acid equivalent).

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Abstract

The invention discloses a gelidium polyphenol supercritical CO2 extraction optimization technology and an application of gelidium polyphenol serving as an alpha-glucosidase inhibitor. A gelidium polyphenol extract serves as one active component or sole active component for preparing the alpha-glucosidase inhibitor. The gelidium polyphenol supercritical CO2 extraction optimization technology includes the step: extracting 75% ethyl alcohol at the temperature of 60 DEG C as an entrainer. Extraction time is 2.5 hours, the flow rate of the entrainer is 1.5mL / min, and extraction pressure is 20MPa. Inhibitory kinetics and thermodynamic experimental results of the gelidium polyphenol for alpha-glucosidase activity provide reliable experimental and theoretical bases for the application of the gelidium polyphenol to the field of postprandial blood sugar level reduction, and also provide new approaches of higher value application of gelidium resources and development of economical, safe and marine-derived alpha-glucosidase inhibitors.

Description

technical field [0001] The invention relates to the technical fields of food chemistry, medicinal chemistry and biochemistry, and in particular to the use of the polyphenol extract of agaricus as an alpha-glucosidase inhibitor. Background technique [0002] Seaweed polyphenols are one of the main secondary metabolites of marine plants, which have significant anti-oxidation, anti-tumor, blood lipid-lowering, anti-inflammatory, anti-virus, anti-thrombotic and anti-arteriosclerosis biological activities, and toxicological tests have proved that seaweed Polyphenols are low-toxic chemical substances, safe to eat, and have been widely used in food, medicine, and daily chemicals. [0003] Agaricus is a kind of red algae with the same source of medicine and food. It is the main raw material for producing agar. In addition to containing agar polysaccharide, it is also rich in polyphenols with various physiological activities. As an important renewable resource plant, Geliflower wide...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/04A61P3/10A23L33/105
CPCA23V2002/00A61K36/04A61K2236/37A61K2236/51A61K2236/55A23L33/105A61P3/10A23V2200/328A23V2250/202A23V2300/14
Inventor 范和良孔亚芬莫翠萍原凤兰刘梦晓何江业李思颖李恒悦刘炬良
Owner BEIBU GULF UNIV
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