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Microneedle device

A technology of microneedling and coating, applied in the direction of microneedles, needles, medical preparations with non-active ingredients, etc.

Active Publication Date: 2019-08-09
HISAMITSU PHARM CO INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Previously, the use of microneedle devices for transdermal administration of dexmedetomidine has not been studied

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0037] (Fabrication of microneedle device)

[0038] In the following examples, microneedle devices were fabricated as follows.

[0039] The coating-forming ingredients are mixed with an appropriate amount of purified water (and, if necessary, ethanol) to obtain a coating composition solution. Furthermore, the tips of the microneedles are dipped in the solution and air-dried to form a coating on the microneedles. The dipping was performed so that the amount of dexmedetomidine hydrochloride in the coating was about 30 to 60 μg.

[0040] (Analysis of the rising rate of dexmedetomidine concentration)

[0041] In the following examples, the rate of increase in the concentration of dexmedetomidine (Dex) in plasma was analyzed as follows.

[0042]1) A microneedle device was applied to the shaved ventral skin of male dogs, and blood was collected 5, 10, 20, 30, 60, and 90 minutes later.

[0043] 2) The dexmedetomidine in the plasma is quantified by liquid chromatography-mass spect...

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Abstract

The microneedle device according to the present invention comprises: a substrate, a microneedle disposed on the substrate, and a coating formed on the microneedle, the coating containing dexmedetomidine or a pharmaceutically acceptable salt thereof, and isoproterenol or a pharmaceutically acceptable salt thereof. Using said microneedle device results in a rapid increase in plasma dexmedetomidine concentration following application of the microneedle device.

Description

technical field [0001] The invention relates to a microneedle device. Background technique [0002] Dexmedetomidine acts on alpha 2 Adrenergic receptors, exhibits a sedative effect. Dexmedetomidine is used, for example, for sedation during artificial respiration and after weaning during intensive care, or sedation during non-intubated surgery or treatment under local anesthesia. For the purposes of this use, dexmedetomidine is supplied as a hydrochloride salt as a liquid formulation for intravenous injection. [0003] On the other hand, as a form for administering a drug, transdermal administration using a microneedle device is known (for example, Patent Document 1). The microneedle device punctures a microneedle into the stratum corneum located in the outermost layer of the skin to form microscopic holes through which a drug passes, whereby the drug can be administered transdermally. Previously, the use of microneedle devices for transdermal administration of dexmedetom...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4174A61L31/08A61M37/00A61P25/20
CPCA61K31/4174A61L31/08A61M37/00A61P25/20A61K9/0021A61K47/20A61K47/183A61M37/0015A61K47/02A61K31/137A61L31/16A61M2037/0023A61M2037/0046A61K31/135A61M2037/0053
Inventor 堀良太木暮敏博德本诚治西村真平
Owner HISAMITSU PHARM CO INC
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