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A kind of regenerative medicine material and preparation method thereof

A medical material, calcium oxide technology, applied in the field of biomaterials, can solve problems such as easy agglomeration, wide particle distribution range, difficult to control powder particle size, etc., achieve high dispersion, synchronized cell proliferation, and reduce hard agglomeration effects

Active Publication Date: 2021-03-23
BEIJING BEST LIFE REGENERATIVE MEDICINE TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method is the main preparation technology of current regenerative medical materials. For example, the patent: Nano Mesoporous-Macroporous Composite Bioglass and Its Preparation Method (Patent No.: CN200310122616.8) introduces this method, but the material prepared by this method There are disadvantages such as difficulty in controlling the particle size of the powder, a wide range of particle distribution, and easy agglomeration

Method used

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  • A kind of regenerative medicine material and preparation method thereof
  • A kind of regenerative medicine material and preparation method thereof
  • A kind of regenerative medicine material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] A nano regenerative medical material prepared by a template-solvent replacement method, the preparation method of which is as follows:

[0038] (1) The template agent octadecyltrimethylammonium chloride is added to deionized water, fully stirred to make it dissolve completely, forming a uniform mixed solution, and then adding ammonia water (referring to an aqueous solution containing 28wt% ammonia), Stir well to make it evenly mixed, then add ethyl orthosilicate and stir evenly, then add triethyl phosphate and stir evenly, finally add calcium nitrate tetrahydrate and stir evenly, the temperature of the water bath is 15°C, the stirring speed is 1000rpm, the reaction time Under the condition of 8 hours, the reaction is carried out while stirring, and the suspension liquid of the nano regenerative medical material precursor is obtained after fully hydrolyzing and polymerizing. Among them, the molar ratio of ethyl orthosilicate, calcium nitrate tetrahydrate, and triethyl ph...

Embodiment 2

[0050] A nano regenerative medical material prepared by a template-solvent replacement method, the preparation method of which is as follows:

[0051] (1) Add the template agent hexamethylenetetramine into deionized water, stir fully to dissolve it completely, and form a uniform mixed solution, then add sodium hydroxide to it, stir well to make it evenly mixed, and then add normal Methyl silicate, after stirring evenly, add diammonium hydrogen phosphate, then add calcium chloride after stirring evenly, and react while stirring under the condition that the temperature of the water bath is 20°C, the stirring speed is 5000rpm, and the reaction time is 6h. After it is fully hydrolyzed, the suspension liquid of the nano regenerative medical material precursor is obtained. The molar ratio of methyl orthosilicate, calcium chloride, and diammonium hydrogen phosphate is 90:4:6, the molar ratio of water to methyl orthosilicate is 100:1, and the molar ratio of sodium hydroxide to water i...

Embodiment 3

[0058] A nano regenerative medical material prepared by a template-solvent replacement method, the preparation method of which is as follows:

[0059] (1) The template agent quinuclidine is added to deionized water, fully stirred to make it completely dissolved to form a uniform mixed solution, then triethanolamine is added thereto, fully stirred to make it evenly mixed, and then silicic acid is added to stir evenly, Then add phytic acid and stir evenly, and finally add calcium acetate and stir evenly. Under the conditions of water bath temperature of 25°C, stirring speed of 10,000rpm, and reaction time of 4h, the reaction is carried out while stirring, so that it can be fully hydrolyzed to obtain nano regenerative medical materials. Precursor suspension. Among them, the molar ratio of silicic acid, calcium acetate, and phytic acid is 70:22:8, the molar ratio of water to silicic acid is 40:1, the molar ratio of triethanolamine to water is 1:500, and the molar ratio of quinucli...

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Abstract

The invention discloses a regenerative medicine material and a preparing method thereof. The regenerative medicine material comprises silicon oxide, calcium oxide and phosphorus pentoxide, wherein themole ratio of the silicon oxide to the calcium oxide to the phosphorus pentoxide is (60-90):(1-40):(0.5-5). The regenerative medicine material has a nano structure, the primary particle size of the regenerative medicine material is 0.1-60 nm, and the secondary particle size of the regenerative medicine material is 0.1-100 micrometers. The preparing method of the regenerative medicine material comprises the steps of self-assembly of raw materials, solid-liquid separation, replacement of an organic solvent and high-temperature heat treatment. By means of the nano regenerative medicine material,quick regeneration of cells of impaired tissue can be induced, and the in-situ repair function of the tissue is achieved.

Description

technical field [0001] The invention belongs to the technical field of biomaterials, and in particular relates to a regenerative medical material with large specific surface area and controllable degradation cycle and a preparation method thereof. Background technique [0002] The invention relates to a special silicate regenerative medical material with tissue repair function. This material was originally obtained by the fusion method in the 1970s by Professor Hench of the University of Florida in the United States. The material is called 45S5 biological Glass (mass fraction is 24.5% Na 2 O-24.5%CaO-45%SiO 2 -6%P 2 o 5 ). This material has good biocompatibility and bioactivity, and is widely used in bone, tooth and skin tissue repair and other fields. However, this material needs to be obtained by melting the mixed raw materials at extremely high temperature (1300-1500°C), so the obtained material has high process energy consumption, many impurities, dense and non-poro...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/12A61L27/56A61L27/58A61L27/50
CPCA61L27/12A61L27/50A61L27/56A61L27/58A61L2400/08
Inventor 胡方余玲华仇越秀
Owner BEIJING BEST LIFE REGENERATIVE MEDICINE TECH CO LTD
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