Preparation method of vancomycin-modified copper sulphide nanoparticles

A technology of vancomycin and nanoparticles, applied in the field of nanometers, can solve the problems of reducing the stability and biocompatibility of copper sulfide nanoparticles, low efficiency, cumbersome process, etc., achieve good stability and biocompatibility, improve Reaction yield, effect of simplification of synthesis steps

Pending Publication Date: 2019-09-17
LUDONG UNIVERSITY
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Problems solved by technology

In order to accurately locate the treatment site, the copper sulfide nanoparticles obtained by sodium citrate reduction need to undergo subsequent targeted molecular modification, and the modification process has problems such a

Method used

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  • Preparation method of vancomycin-modified copper sulphide nanoparticles
  • Preparation method of vancomycin-modified copper sulphide nanoparticles
  • Preparation method of vancomycin-modified copper sulphide nanoparticles

Examples

Experimental program
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Embodiment 1

[0027] A preparation method of copper sulfide nanoparticles modified by vancomycin, the steps are as follows:

[0028] Add 80mL, 50mmol / L vancomycin solution and 20mL, 6mmol / L cupric chloride solution into a 200mL Erlenmeyer flask, mix, stir at 18-25°C until the solution changes from colorless to light blue; continue to add 1.0mL , 3mol / L sodium sulfide nonahydrate solution, the solution instantly changes from blue to brownish yellow; when stirred in a boiling water bath, the solution changes from brownish yellow to dark green, and after discoloration, ice baths and terminates the reaction to obtain vancomycin-modified copper sulfide nanoparticles.

[0029] figure 1 (b) is the ultraviolet-visible spectrogram of the copper sulfide nanoparticles modified by vancomycin obtained in this example; figure 1 (a) Its TEM and dynamic light scattering images.

[0030] Depend on figure 1 It can be seen that vancomycin-modified copper sulfide nanoparticles (CuS@Van) have an obvious abs...

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Abstract

The invention belongs to the field of nanotechnology, and particularly relates to a preparation method of vancomycin-modified copper sulfide nanoparticles. Vancomycin is adopted as a reducing agent and a wrapping agent, and a one-step method is used for preparation, the copper sulfide nanoparticles are synthesized, and meanwhile surface decoration of the vancomycin is achieved; the synthesis step is synthesized, the reaction yield is improved, and obtained vancomycin-modified copper sulfide nanoparticles have high purity and good stability and biocompatibility, and can be used for photothermal therapy of vancomycin resistant bacteria.

Description

technical field [0001] The invention belongs to the field of nanotechnology, in particular to a preparation method of vancomycin-modified copper sulfide nanoparticles. Background technique [0002] Vancomycin (Van for short) is a class of glycopeptide antibiotics used to prevent and treat Gram-positive pathogenic bacteria infections. Because vancomycin has strong sterilizing activity and is not easy to make bacteria resistant, it is only allowed to be used when other antibiotics cannot treat bacterial infections, so it is called "the last line of defense of antibiotics". However, with the overuse of vancomycin in clinical practice, reports of vancomycin-resistant Enterococci (VRE), a "superbug", have appeared in succession all over the world. Due to the lack of effective preventive measures and regulatory mechanisms, VRE drug-resistant strains spread rapidly all over the world, and the number is increasing year by year. At present, the incidence of VRE infection in my coun...

Claims

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Application Information

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IPC IPC(8): A61K38/14A61K41/00A61P31/04C01G3/12B82Y40/00B82Y30/00
CPCA61K38/14A61K41/0052A61P31/04C01G3/12B82Y40/00B82Y30/00C01P2004/04C01P2002/84C01P2002/85C01P2002/82C01P2004/64A61K2300/00
Inventor 江婷婷邹忠浩王娟
Owner LUDONG UNIVERSITY
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