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Coumarin compound, preparation method, and application of coumarin compound in preparing medicines for treating cerebral apoplexy

A technology of coumarins and compounds, which is applied in the preparation and preparation of drugs for the treatment of stroke, in the field of coumarins, can solve the problems of weak stroke treatment system and inability to achieve effective treatment by thrombolytic therapy

Active Publication Date: 2019-09-20
FOURTH MILITARY MEDICAL UNIVERSITY
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Problems solved by technology

For many patients, especially in poverty-stricken and grassroots areas with relatively backward medical conditions and relatively weak stroke treatment systems, patients often have exceeded the "treatment time window" when they seek medical treatment, and the existing thrombolytic therapy is far from achieving the purpose of effective treatment

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  • Coumarin compound, preparation method, and application of coumarin compound in preparing medicines for treating cerebral apoplexy
  • Coumarin compound, preparation method, and application of coumarin compound in preparing medicines for treating cerebral apoplexy
  • Coumarin compound, preparation method, and application of coumarin compound in preparing medicines for treating cerebral apoplexy

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Embodiment Construction

[0031] IS early brain protection therapy and thrombolytic therapy are equally important. Thrombolytic reflow is the prerequisite for successful treatment of IS in the acute phase, while brain protection treatment is the decisive factor affecting the prognosis of patients. To successfully save brain tissue, the two complement each other and are indispensable. Brain protection therapy blocking the ischemic cascade chain mediated by oxidative stress (OS) is the key to effective treatment of IS. Brain protection is to block IS ischemic cascade cascade reaction from one or more targets (calcium overload, oxidative free radical activation, neuron death), and block or reverse the pathological process of ischemic penumbra neurons. Neuronal OS injury after IS is a key step in initiating a series of pathological cellular programs (including inflammation, apoptosis, and autophagy, etc.). If this damage can be blocked and the antioxidant capacity of brain tissue can be improved, it can n...

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Abstract

The invention provides a coumarin compound, a preparation method, and an application of the coumarin compound in preparing medicines for treating cerebral apoplexy. The main purpose of the invention is to provide ideal ischemic stroke (IS) brain protection medicines conforming to partial or all standards, wherein the ideal IS brain protection medicines have a multi-layer effect (such as an antioxidant effect), can non-selectively block acute IS cascade reactions caused by oxidative stress (OS), can remarkably reduce the cerebral infarction volume, do not influence the vascular tension or cause bleeding events in research processes, promotes brain tissue to metabolize toxicity substances, have slight side effects, do not need differential diagnosis before being used, and consequentially make early-stage treatment efficient and feasible.

Description

technical field [0001] The invention belongs to the field of chemical medicines, and specifically relates to coumarin compounds, a preparation method and the application of preparing medicines for treating cerebral apoplexy. Background technique [0002] In recent years, the incidence of stroke in my country has ranked first in the world. The results of the third national cause of death survey confirmed that stroke has become the first cause of death in my country, and the annual growth rate exceeds 8.7%, which has seriously affected the lives and health of Chinese people. Stroke is mainly divided into two types: ischemic stroke (IS) and hemorrhagic stroke (HS). Among them, IS type patients account for three-quarters of the total incidence of patients and are the main cause of stroke. Types of. The key to the treatment of IS is "early diagnosis and early intervention". Various current treatments try to save the ischemic brain tissue by recanalizing the blood flow of the ear...

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Application Information

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IPC IPC(8): C07D311/56A61P9/10A61P39/06
CPCA61P9/10A61P39/06C07D311/56
Inventor 李侠王钧李明凯张文彤马波樊朝阳
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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