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Drug for relieving pseudomonas aeruginosa keratitis

A technology of Pseudomonas aeruginosa and Pseudomonas aeruginosa, applied in the fields of microbiology and ophthalmology, can solve problems such as corneal perforation, irreversible tissue, damage, etc., and achieve the effect of alleviating the disease, inhibiting proliferation and virulence

Pending Publication Date: 2019-09-24
SHANDONG EYE INST
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

These inflammatory mediators promote bacterial clearance but, if left unchecked, can lead to tissue damage and corneal perforation
At this point, conventional therapies, such as antibiotic therapy, may often fail to reverse tissue damage caused by inflammation, even when bacteria are cleared from the cornea

Method used

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  • Drug for relieving pseudomonas aeruginosa keratitis
  • Drug for relieving pseudomonas aeruginosa keratitis
  • Drug for relieving pseudomonas aeruginosa keratitis

Examples

Experimental program
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Embodiment Construction

[0018] The present invention will be further described below in combination with specific embodiments and accompanying drawings.

[0019] A medicine for alleviating Pseudomonas aeruginosa corneal inflammation, comprising a β2 adrenergic receptor inhibitor, the structure of the β2 adrenergic receptor inhibitor is:

[0020]

[0021] By administering the β2 adrenergic receptor inhibitor ICI118551, the bacterial proliferation and virulence expression of Pseudomonas aeruginosa in the cornea were inhibited, and the number of infiltrating neutrophils and the expression of inflammatory factors in the cornea were reduced to reduce the severity of keratitis.

[0022] Tissue damage will lead to increased secretion of catecholamines in the body and increase the infection rate of opportunistic infections. Norepinephrine is a type of catecholamines. Studies have shown that norepinephrine can aggravate infections by promoting the proliferation and virulence of Pseudomonas aeruginosa , In ...

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Abstract

The invention discloses a drug for relieving pseudomonas aeruginosa keratitis. Bacterial proliferation and virulence expression of pseudomonas aeruginosa in the cornea are inhibited by applying a beta2 adrenergic receptor inhibitor, the number of neutrophils infiltrated in the cornea and the expression of inflammatory factors are decreased to reduce the severity of the keratitis. The drug can inhibit bacterial proliferation in the cornea and improve inflammatory reaction in the cornea, thereby reducing inflammatory reaction of the pseudomonas aeruginosa keratitis, and is a novel drug for relieving the pseudomonas aeruginosa keratitis.

Description

technical field [0001] The invention belongs to the technical fields of microbiology and ophthalmology, in particular to a medicine for alleviating corneal inflammation caused by Pseudomonas aeruginosa. Background technique [0002] Pseudomonas aeruginosa (Pseudomonas aeruginosa) is a common causative agent of keratitis, accounting for nearly 38% of infectious keratitis cases. Pseudomonas aeruginosa corneal ulcers are considered more severe than other bacterial corneal ulcers and develop rapidly through purulent infiltration, which can lead to corneal erosion, perforation, and loss of vision. These consequences are caused by a combination of host inflammatory responses and bacterial toxins. The pathogenesis of keratitis caused by P. aeruginosa includes virulence factors, extracellular products, and cellular structures of P. aeruginosa, such as proteases, exotoxin A, biofilm, and flagella. Among these factors, proteases, including metalloproteases such as alkaline protease,...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61P27/02A61P31/04
CPCA61K45/00A61P27/02A61P31/04
Inventor 周庆军马修彬谢立信王群
Owner SHANDONG EYE INST
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