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Application of a composition in the preparation of medicines for preventing and/or treating fever with thrombocytopenia syndrome virus

A combination and syndrome technology, applied in the field of medicine, can solve problems such as large individual differences, limited treatment methods, and limited efficacy

Active Publication Date: 2021-06-15
军事科学院军事医学研究院微生物流行病研究所 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the treatment methods for SFTSV infection are also quite limited. The main treatment methods are symptomatic supportive treatment and broad-spectrum antiviral therapy. The curative effect is limited and individual differences are large.

Method used

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  • Application of a composition in the preparation of medicines for preventing and/or treating fever with thrombocytopenia syndrome virus
  • Application of a composition in the preparation of medicines for preventing and/or treating fever with thrombocytopenia syndrome virus
  • Application of a composition in the preparation of medicines for preventing and/or treating fever with thrombocytopenia syndrome virus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] This embodiment provides a medicine, which is prepared by a composition and auxiliary materials, and the composition includes nifedipine. The concentration of nifedipine in the composition is 150 μMol / L.

[0059] The above-mentioned drugs can prevent and / or treat fever with thrombocytopenia syndrome virus.

Embodiment 2

[0061] This embodiment provides a medicine, which is prepared through a composition and auxiliary materials, and the composition includes 170 μMol / L of nifedipine.

[0062] The above-mentioned drugs can prevent and / or treat fever with thrombocytopenia syndrome virus. Correspondingly, the above drugs can inhibit the replication of fever with thrombocytopenia syndrome virus.

Embodiment 3

[0064] This embodiment provides a medicine, which is prepared through a composition and auxiliary materials, and the composition includes 170 μMol / L of nifedipine.

[0065] The above-mentioned drugs can prevent and / or treat fever with thrombocytopenia syndrome virus.

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Abstract

The present application relates to the field of medicine, in particular to the application of a composition in the preparation of a drug for preventing and / or treating fever with thrombocytopenia syndrome virus. The application of the composition in the preparation of medicines for preventing and / or treating fever with thrombocytopenia syndrome virus, the composition includes nifedipine or its pharmaceutically acceptable salt, solvate or hydrate. The present application provides a new application of nifedipine or its pharmaceutically acceptable salt, solvate or hydrate, which can be used to prepare medicines for preventing and / or treating fever with thrombocytopenia syndrome virus.

Description

technical field [0001] The present application relates to the field of medicine, in particular to the application of a composition in the preparation of a drug for preventing and / or treating fever with thrombocytopenia syndrome virus. Background technique [0002] SFTSV (Severe Fever with Thrombocytopenia Syndrome Virus, SFTSV), the main symptoms caused by SFTSV infection include fever, bleeding, gastrointestinal discomfort, muscle pain, lymph node enlargement, thrombocytopenia and leukopenia, etc.; the virus is mainly carried and transmitted by ticks , Tick bites are an important cause of human infection. SFTSV can infect people of almost all age groups, especially the elderly, and has a high mortality rate. SFTSV belongs to the order Bunyavirales, the family Phenuiviridae, and the genus Phlebovirus. It is a negative-strand RNA virus with a segmented genome. The genome is divided into three segments (L, M, S) according to the length, and is wrapped with nucleocapsid protei...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4422A61K9/20A61P31/14A61P29/00A61P7/04
CPCA61K9/20A61K31/4422A61P7/04A61P29/00A61P31/14
Inventor 刘玮彭珂黎浩李淑芬肖庚富张磊砢陈远侨张玉兰万伟玮
Owner 军事科学院军事医学研究院微生物流行病研究所
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