Fullerol and composition thereof in preparing antithrombotic drugs
A technology of fullererol and its composition, which is applied in the field of application of fullererol and its composition in the preparation of antithrombotic drugs, can solve the problems of old thrombus dissolving effect, short half-life, etc. that easily cause bleeding, and achieve good biological safety , good blood safety, and the effect of prolonging the half-life of blood
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[0048] Example 1:
[0049] Preparation of thrombus suppression composition:
[0050] Required components: Fullerol, mesoporous silicon, red blood cell membrane and platelet membrane, the general formula of fullerol is C 60 (OH) X , Where 10≤X<40.
[0051] Preparation:
[0052] In the first step, blood is taken from the rat heart, and red blood cells and platelets are obtained by centrifugation. The hypotonic solution is added and placed in liquid nitrogen. The cells are subjected to repeated freezing and thawing 5 times to remove the cell contents to obtain the red blood cell membrane and the platelet membrane.
[0053] The second step is to synthesize mesoporous silicon of about 140nm, mix the mesoporous silicon and fullerol in a ratio of 1:1, and stir for 24 hours at room temperature. Add erythrocyte membrane and platelet membrane and sonicate for 2 minutes. The mixed system was added to a dialysis bag with a molecular weight cut-off of 3500 for 72 hours, and the disguised nano drug...
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[0054] Example 2:
[0055] Preparation of thrombus suppression composition:
[0056] Required components: Fullerol, mesoporous silicon, red blood cell membrane, platelet membrane and solvent physiological saline. The general formula of fullerol is C 60 (OH) X , Where 10≤X<40.
[0057] Preparation:
[0058] The thrombus suppression composition in Example 1 is dispersed in physiological saline to obtain it.
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