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Fullerol and composition thereof in preparing antithrombotic drugs

A technology of fullererol and its composition, which is applied in the field of application of fullererol and its composition in the preparation of antithrombotic drugs, can solve the problems of old thrombus dissolving effect, short half-life, etc. that easily cause bleeding, and achieve good biological safety , good blood safety, and the effect of prolonging the half-life of blood

Active Publication Date: 2019-10-01
INST OF HIGH ENERGY PHYSICS CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] At present, the thrombolytic (that is, the same as dissolving thrombus) drugs in the prior art have achieved remarkable results in the treatment of thrombus, but there are still a series of problems such as short half-life, easy to cause bleeding, and poor dissolution effect on old thrombus.

Method used

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  • Fullerol and composition thereof in preparing antithrombotic drugs
  • Fullerol and composition thereof in preparing antithrombotic drugs
  • Fullerol and composition thereof in preparing antithrombotic drugs

Examples

Experimental program
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Effect test

Embodiment 1

[0049] Preparation of Thrombostatic Composition:

[0050] Required components: fullerenol, mesoporous silicon, erythrocyte membrane and platelet membrane, the general formula of fullerenol is C 60 (OH) X , wherein, 10≤X<40.

[0051] Preparation:

[0052] The first step is to collect blood from the heart of rats, and separate red blood cells and platelets by centrifugation, add hypotonic solution, put them in liquid nitrogen, and freeze and thaw repeatedly 5 times to remove the cell contents to obtain red blood cell membranes and platelet membranes.

[0053] The second step is to synthesize mesoporous silicon with a thickness of about 140 nm, mix mesoporous silicon and fullerenol in a ratio of 1:1, and stir at room temperature for 24 hours. Add erythrocyte membrane and platelet membrane and sonicate for 2 minutes. The mixed system was added to a dialysis bag with a molecular weight cut off of 3500 and dialyzed for 72 hours, and the camouflaged nano drug-loaded particles wer...

Embodiment 2

[0055] Preparation of Thrombostatic Composition:

[0056] Required components: fullerene alcohol, mesoporous silicon, erythrocyte membrane, platelet membrane and solvent saline, the general formula of fullerene alcohol is C 60 (OH) X , wherein, 10≤X<40.

[0057] Preparation:

[0058] It is obtained by dispersing the antithrombotic composition in Example 1 in physiological saline.

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Abstract

The invention discloses application of fullerol and a composition thereof in preparing antithrombotic drugs, and relates to the technical field of medicine. Specifically, the application of the fullerol C60(OH)X in preparing drugs for dissolving thrombus and / or inhibiting thrombosis is studied, wherein X is larger than or equal to 10 and less than 40, and the drugs comprise the fullerol and / or meso-porous silicon and / or cytomembrane; further more, it is found that the components of a composition used for inhibiting and / or dissolving the thrombus mainly comprise the fullerol, the meso-porous silicon, erythrocyte membrane and platelet membrane, and can also comprise a solvent and / or a pharmaceutically acceptable carrier. In the application of the composition in preparing the antithrombotic drugs, the drugs can be prepared into various dosage forms, and the dosage amounts corresponding to the dosage forms are 0.4 mg / kg / day in terms of the fullerol. It is found through studies that the fullerol has obvious thrombolytic and antithrombotic effects, the targeting and enrichment of the thrombus can be enhanced by loading biological membranes with fullerol nanomedicine, and a good thrombolytic effect is achieved.

Description

technical field [0001] The invention relates to the technical field of application of medicines, in particular to the application of fullerenol and its composition in the preparation of antithrombotic medicines. Background technique [0002] When the pathological process can no longer be regulated by the hemostatic regulation mechanism, a large amount of thrombin will be produced, thereby triggering the formation of thrombus. Thrombosis is an important factor in the development of cardiovascular diseases, such as arterial diseases such as myocardial infarction and stroke, and venous thromboembolic disorders, and the formation of thrombus leads to high morbidity and mortality. In addition, venous thrombosis is one of the leading causes of death in cancer patients. [0003] The formation of thrombus is related to many factors, including platelets, fibrin, collagen, tissue factor and thrombin. When the vessel wall is damaged or the endothelium is destroyed, collagen and tissu...

Claims

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Application Information

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IPC IPC(8): A61K33/44A61P7/02A61P9/10A61K47/69A61K9/50A61K47/46
CPCA61K9/5068A61K33/44A61K47/6923A61P7/02A61P9/10
Inventor 陈奎王玉娇邢更妹
Owner INST OF HIGH ENERGY PHYSICS CHINESE ACADEMY OF SCI
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