3D bioprinting implant gel and its application in soft tissue defect repair

A composition and concentration technology, applied in tissue regeneration, drug delivery, prosthesis, etc., can solve problems such as lack, and achieve the effects of avoiding effusion, reducing the risk of infection, and good biocompatibility

Active Publication Date: 2021-06-29
SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] For the repair of defective soft tissue, there is still a lack of effective methods in clinical practice, such as: materials that can fill soft tissue cavities, so that the soft tissue cavities formed after surgery can be filled, thereby promoting the healing of soft tissue at the trauma site

Method used

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  • 3D bioprinting implant gel and its application in soft tissue defect repair
  • 3D bioprinting implant gel and its application in soft tissue defect repair
  • 3D bioprinting implant gel and its application in soft tissue defect repair

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Embodiment 1

[0027] 2.5w / v% PEG, 20w / v% decellularized extracellular matrix, 15g / L hyaluronic acid, 2.5w / v% PEG+20w / v% decellularized extracellular matrix, 2.5w / v% PEG+ 15g / L hyaluronic acid, 20w / v% decellularized extracellular matrix + 15g / L hyaluronic acid, 2.5w / v% PEG + 5w / v% decellularized extracellular matrix + 15g / L hyaluronic acid, 2.5w / v% PEG+10w / v% acellular extracellular matrix+15g / L hyaluronic acid, 2.5w / v% PEG+20w / v% acellular extracellular matrix+15g / L hyaluronic acid, and blank control group After 10 groups were treated with gelation, 10 groups of rats (5 in each group) were implanted into the quadriceps femoris frostbite defect site, and the cross-sectional area of ​​the rat skeletal muscle was observed after 1 month as a way to judge the healing of the muscle defect. The basis of pros and cons, and corresponding statistical analysis, see image 3 . Such as image 3 As shown, the rats in the 2.5w / v% PEG+20w / v% decellularized extracellular matrix+15g / L hyaluronic acid gel...

Embodiment 2

[0029] Mix 2.5w / v% PEG, 20w / v% decellularized extracellular matrix and 15g / L hyaluronic acid solution, mix and stir for 24 hours to prepare PEG / decellularized extracellular matrix / hyaluronic acid hydrogel, which Store at 4°C. It is fluid at 4°C, suitable for injection, and becomes gelatinized at 37°C.

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Abstract

A composition comprising a solution of polyethylene glycol, decellularized extracellular matrix and hyaluronic acid. Wherein, the polyethylene glycol concentration is 1.5w / v%-3.5%w / v, the decellularized extracellular matrix concentration is 10w / v%-30w / v%, and the hyaluronic acid concentration is 10g / L-20g / L. The composition of the present invention has good biocompatibility and temperature-sensitive properties. As the temperature rises, it gradually solidifies. It is made into a gel simulating the shape of extracellular matrix by using 3D printing technology, which is beneficial to the void formed after soft tissue resection. Adhesive growth and regenerative repair of new granulation tissue in the cavity to promote wound healing.

Description

technical field [0001] The present invention relates to a composition, in particular to a composition for implantation, which can be made into a gel for soft tissue repair. Background technique [0002] Malignant tumors are a highly lethal disease. Surgery is an effective way to treat malignant tumors. Tumor surgery often requires extensive resection of tumors and surrounding tissues, which means that huge soft tissue defects will result after surgery. After surgery, the cavity formed by the resection of soft tissue is very easy to form dead space, and fluid accumulation in the cavity increases the risk of complications such as postoperative infection, which is not conducive to wound regeneration and healing. [0003] Chinese invention patent application 201811170902.4 discloses a temperature-sensitive hydrogel for cartilage repair, including agarose aqueous solution, gelatin aqueous solution, sodium hyaluronate aqueous solution and DBM-RGD particles, wherein: the mass-volum...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/52A61L27/50A61L27/54A61L27/18A61L27/36A61L27/20B33Y10/00B33Y70/10
CPCA61L27/18A61L27/20A61L27/3633A61L27/3641A61L27/367A61L27/50A61L27/52A61L27/54A61L2300/252A61L2300/254A61L2300/30A61L2300/414A61L2300/418A61L2400/06A61L2430/30A61L2430/34B33Y10/00B33Y70/00C08L71/02C08L5/08
Inventor 贺超郝永强王磊
Owner SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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