Buffer distribution structure of chromatographic column

Abstract

The invention discloses a buffer distribution structure of a chromatographic column. The buffer distribution structure is mounted at the upper end of the chromatographic column and located above solid-phase particles. The buffer distribution structure structurally comprises a buffer cap, a primary distribution plate and a secondary distribution plate from top to bottom and is characterized in thatthe middle of the buffer cap is upwardly arched, the periphery of the buffer cap is provided with liquid leakage holes, the primary distribution plate is provided with a plurality of primary distribution holes, the secondary distribution plate is provided with a plurality of mounting holes, the primary distribution and the secondary distribution plate are arranged at intervals to form a feed liquid buffer area, pressure-sensing flow discharge switches are detachably mounted on the mounting holes of the secondary distribution plate, and the pressure-sensing flow discharge switches are switchedon or off by sensing the pressure of the feed liquid buffer area. The buffer distribution structure can buffer liquid entering the chromatographic column and is uniform in distribution, and accordingly resin utilization rate of each part in the chromatographic column is identical.

Description

technical field [0001] The invention relates to a buffer distribution structure, in particular to a buffer distribution structure of a chromatographic column. Background technique [0002] Cannabidiol (CBD), a cannabinoid found in the cannabis plant, is gaining popularity as an alternative treatment for common ailments. Unlike tetrahydrocannabinol (THC), another cannabinoid found in the cannabis plant, CBD has no psychoactive effects. However, when CBD is ingested, only 20% is absorbed, which means that for CBD to be more effective, extraction and isolation of CBD must be performed. In the process of extraction and separation, a chromatographic column is needed. The principle of the distributor in the traditional chromatographic process is similar to the principle of the shower we use every day. However, due to the unstable flow rate of the pipeline at the top of the chromatographic column, the distributor will distribute to The phenomenon that the liquid in the chromatogr...

AI Technical Summary

Problems solved by technology

In the process of extraction and separation, a chromatographic column is needed. The principle of the distributor in the traditional chromatographic process is similar to the principle of the shower we use every day. However, due to the unstable flow rate of the pipeline at the top of the chromatographic column, the distributor will distribute to Inhomogeneity of the liquid in the chromatography column

When the liquid output from the top pipe is large, the local flow rate is too large, so that when the liquid enters the resin in the chromatography column, the flow rate in some areas is too large, resulting in uneven chromatography

When the output volume of the top pipe is small, the distributor does not have enough volume to distribute, which will also cause uneven resin entry, resulting in poor chromatography

And when the liquid is distributed from the distributor into the chromatography column, it flows directly from the middle of the chromatography column, so that the use of the resin in the chromatography column is uneven, and the resin in the middle of the chromatography column is used frequently, while the surrounding resin is less. low usage

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