Application of finerenone in preparation of drugs for treatment of senile calcific valvular heart diseases
A valvular disease and drug technology, which is applied in the application field of finerenone in the preparation of a drug for treating senile calcific valvular heart disease, can solve problems such as undisclosed finerenone senile calcific valvular heart disease, and achieves reduction of various indicators, Improve the quality of life and improve the effect of disease
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0025] Example 1 Experimental Research on the Protective Effect of Finerenone on Myocardium of Rats
[0026] 1. Materials and methods
[0027] 1.1 Experimental method
[0028] Male white rabbits with big ears were randomly divided into three groups: A (n=8), B (n=8), and C (n=8). Groups A and B were ligated to replicate the myocardial infarction model, and group C was threaded but not ligated. Group A was given finerenone (20mg·kg -1 d -1 After 1 week, the myocardial cell apoptosis index (AI) and the expressions of type Ⅰ and type Ⅲ collagen fibrils (Coll-Ⅰ, Coll-Ⅲ) in the non-infarct area of each group were compared. The hemodynamic indexes [mean systolic pressure (MSP), mean diastolic pressure (MDP), mean arterial pressure (MAP), isovolumic systolic / diastolic index (±dp / dtmax)] of the aorta and left ventricle were compared. Measure and compare changes in aldosterone concentration.
[0029] 1.2 Statistical methods
[0030] All the data are represented by x±s, the comp...
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com