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Reagent kit for risk assessment of breast cancer and application of reagent kit

A risk assessment and kit technology, applied in the direction of microbial determination/inspection, biochemical equipment and methods, etc., can solve problems such as limited scope of use, and achieve the effect of reducing disease burden, fast process, and simple cost

Active Publication Date: 2019-10-15
JIANGSU PROVINCIAL CENT FOR DISEASE CONTROL & PREVENTION PUBLIC HEALTH RES INST OF JIANGSU PROVINCE
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because most breast cancer patients do not have BRCA1 and BRCA2 mutations, the use of this method is limited

Method used

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  • Reagent kit for risk assessment of breast cancer and application of reagent kit
  • Reagent kit for risk assessment of breast cancer and application of reagent kit
  • Reagent kit for risk assessment of breast cancer and application of reagent kit

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The present invention recruited 1753 Chinese women, including 818 cases of breast cancer patients and 935 cases of healthy controls. After the epidemiological investigation, the peripheral blood of each survey subject was collected to extract genomic DNA, and the candidate SNP sites were genotyped by Sequenom MassARRAY molecular weight array technology, and the genotype differences between breast cancer patients and healthy controls were statistically analyzed. The final identification of rs17467825, rs2298850 and rs3755967 loci is closely related to the risk of breast cancer and can be used to assess the risk of breast cancer in female individuals.

[0031] 1. Recruitment of research subjects

[0032]A total of 1753 Chinese women were recruited, including 818 breast cancer patients and 935 healthy controls. The case group comes from the tumor network registration system. It is a newly diagnosed breast cancer patient. According to physical examination, breast color Dop...

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PUM

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Abstract

The invention discloses a reagent kit for risk assessment of breast cancer and an application of the reagent kit. The reagent kit comprises a forward and reverse primer and a single-base extension primer amplifying 3 SNP sites of rs17467825, rs2298850 and rs3755967 at the same time, also comprises PCR reaction liquid, alkaline phosphatase treatment reaction liquid and single-base extension reaction liquid. The reagent kit can detect SNP sites pertinent to female breast cancer in genomes, so as to analyze and assess the pathogenesis risk of the breast cancer of an examinee, high-risk groups ofthe breast cancer are screened out, and further the purpose of preventing or delaying generation and development of the breast cancer can be achieved through scientific tumor preventing measures.

Description

technical field [0001] The invention belongs to the field of public health and preventive medicine, and in particular relates to a kit for assessing the risk of breast cancer and its application in assessing the risk of breast cancer. Background technique [0002] Breast cancer is the most common malignant tumor in women all over the world, and it is also the main cause of death among women, which seriously threatens the life and health of women all over the world. The latest cancer statistics show that in 2018, there were approximately 2.089 million new cases and 627,000 deaths from female breast cancer worldwide, accounting for 24.2% of all malignant tumors in women and 15.0% of deaths, ranking first. The morbidity and mortality of breast cancer continue to be at a high level in developed countries (North America, Oceania, Northern Europe / Western Europe). in an upward trend. The situation of breast cancer in China is also quite severe, and the incidence rate has leapt to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886
CPCC12Q1/6886C12Q2600/156
Inventor 朱政陈福星武鸣周金意
Owner JIANGSU PROVINCIAL CENT FOR DISEASE CONTROL & PREVENTION PUBLIC HEALTH RES INST OF JIANGSU PROVINCE
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