Preparation method and application of phenolic compounds and antiallergic drug

A phenolic compound and anti-allergic technology, applied in the field of anti-allergic drugs and the preparation of phenolic compounds, can solve the problem of low activity of anti-allergic substances, and achieve the effects of rational utilization, rational natural resources, and inhibition of mast cell degranulation

Pending Publication Date: 2019-10-25
THIRD INST OF OCEANOGRAPHY MINIST OF NATURAL RESOURCES +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to overcome the problem of low activity of antiallergic substances in the prior art, the invention provides a kind of application of phenolic compounds, as shown in formula (I)~(III) of phenolic compounds:

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  • Preparation method and application of phenolic compounds and antiallergic drug
  • Preparation method and application of phenolic compounds and antiallergic drug
  • Preparation method and application of phenolic compounds and antiallergic drug

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Embodiment Construction

[0027] In order to make the object, technical solution and technical effect of the present invention clearer, the present invention will be described in detail below in conjunction with the examples. It should be understood that the embodiments described in this specification are only for explaining the present invention, not for limiting the present invention, and the parameters and proportions of the embodiments can be selected according to local conditions and have no substantial influence on the results.

[0028] Preparation of phenolic compounds

[0029] (1) Penicillium griseofulvum (can be purchased from the China Marine Microorganism Culture Collection and Management Center, preservation number: MCCC 3A00225), was added to 100 1L Erlenmeyer flasks containing 100g corn grits and 120mL distilled water, 25 Cultivate statically at ℃ for 62 days, add ethyl acetate to extract, degrease with petroleum ether and methylene chloride, and concentrate under low pressure to obtain 5...

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Abstract

The invention discloses application of phenolic compounds. The phenolic compounds are shown in the formulas (I)-(III). The phenolic compounds are used for preparing anti-allergic drugs. Through research, it is found that the three phenolic compounds have strong inhibition effects on degranulation of mast cells, and can be used for preparing anti-allergic drugs, especially anti-food-allergy drugs;through fermentation of deep-sea fungi, namely penicillium chrysanthum which has rich sources, the three substances with strong anti allergic activity are obtained at the same time, compared with directional synthesis during which a variety of by-products are produced, the preparation method is more suitable for industrial production and natural resources are rationally utilized.

Description

technical field [0001] The invention belongs to the field of pharmaceutical application of marine microorganisms, and in particular relates to a preparation method of a phenolic compound, an application thereof and an antiallergic drug. Background technique [0002] Food allergy refers to a reproducible adverse reaction that can affect different organs of the body caused by the immune system's specific immune response to the allergen after a certain food enters the human body, which can cause urticaria, nasal congestion, itching, wheezing, nausea and vomiting , tachycardia and other multi-system reactions. These reactions can range from mild local reactions to severe, life-threatening reactions. [0003] Food allergy is a global health problem affecting millions. The results of epidemiological studies show that the prevalence of food allergy has been increasing in the past 20 years, and the current recommended treatment for food allergy is still based on strict fasting. B...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/47A61K31/5513A61K31/122C07D491/044C07D215/22C07C49/747A61P37/08C12P7/26C12P17/12C12P17/18C12R1/80
CPCA61K31/47A61K31/5513A61K31/122C07D491/044C07D215/22C07C49/747A61P37/08C12P7/26C12P17/12C12P17/18
Inventor 杨献文邢翠平夏金梅谢春兰罗钦叶德赞
Owner THIRD INST OF OCEANOGRAPHY MINIST OF NATURAL RESOURCES
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