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Effective storage method for traditional Chinese medicine indigo naturalis

A technology of Chinese herbal medicine, Indigo Naturalis, applied in the field of effective storage of Chinese herbal medicine Qingdai, which can solve problems affecting the quality of Qingdai medicinal materials, structural changes, and substandard components

Inactive Publication Date: 2019-10-25
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The active ingredients are exposed on the surface, and affected by environmental factors, the structure will undergo some changes, which will eventually lead to the detection of index components in the content determination, which will affect the quality of Qingdai medicinal materials
Starting from the material basis of Indigo Naturalis, the carbon-carbon double bond in the conjugated system of indigo and indirubin will be destroyed when it is attacked by light or oxidation, causing decolorization, poor stability, and affecting the quality of Indigo Naturalis.

Method used

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  • Effective storage method for traditional Chinese medicine indigo naturalis
  • Effective storage method for traditional Chinese medicine indigo naturalis
  • Effective storage method for traditional Chinese medicine indigo naturalis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The establishment of embodiment 1 indigo and indirubin content determination methodology

[0020] 1. Instruments and reagents

[0021] Shimadzu LC-10A high-performance liquid chromatography, SCL-6A system controller, N2000 chromatography data workstation, TC-100 incubator (Shimadzu, Japan); Agilent 1200 high-performance liquid chromatography (Agilent, USA); MettlerAE240 1 / 100,000 electronic balance (Germany Mettler); FA1104 1 / 10000 electronic balance (Shanghai Balance Instrument Factory); KQ3200 ultrasonic cleaner (Kunshan Ultrasonic Instrument Co., Ltd.);

[0022] Indigo naturalis medicinal material (Yaan Xunkang Co., Ltd.); indigo reference substance (batch number: MUST-12020104, Chengdu Master Biotechnology Co., Ltd.), indirubin reference substance (batch number: MUST-12020803, Chengdu Master Biotechnology Co., Ltd. ), methanol was chromatographically pure, water was redistilled (self-made), and other reagents were analytically pure.

[0023] 2. Chromatographic con...

Embodiment 2

[0031] The difference investigation of embodiment 2 different storage temperature, humidity and storage time

[0032] Weighed 9 parts of Qingdai medicinal material, each 10g, under natural conditions, the three factors of storage temperature, storage humidity and storage time were tested, prepared according to the indigo test solution, and the indigo content was determined. The results are shown in Table 1.

[0033] Table 1 Experimental design and results

[0034]

[0035] According to the test results, it is determined that the storage condition is that the temperature is 25° C. and the humidity is 70% RH, and the storage time is not more than 6 months. The content of indigo in the Qingdai medicinal material is 3.11%.

Embodiment 3

[0036] Example 3 Different lighting conditions difference investigation

[0037] Weigh 10g of Qingdai medicinal material, store it at 25°C and 70%RH, place it under the conditions of ultraviolet light, natural light, and light-proof (use aluminum foil laminated bags) respectively, and take samples for determination every 24h (every 1h under ultraviolet conditions) Sampling) The content of indigo and isatin in medicinal materials was repeated three times in parallel, and the average value was used for calculation. The results are shown in Table 2 and Table 3.

[0038] The influence (n=3) of different light conditions of table 2 on indigo content

[0039]

[0040] The influence of table 3 different light conditions on indirubin content (n=3)

[0041]

[0042]The above data show that under natural light conditions, the content of indigo decreases slowly, and after 72 hours, the degradation of indigo reaches more than 60% of the initial content, while the degradation of in...

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Abstract

The invention provides an effective storage method for a traditional Chinese medicine indigo naturalis. The traditional Chinese medicine is stored under 25 DEG C and 70% RH through light avoiding andanti-oxidation treatment. The indigo content of the traditional Chinese medicine is not lower than 2%, and the indirubin content of the traditional Chinese medicine is not lower than 0.3%. The indigocontent and the indirubin content of the indigo naturalis are increased, in addition, the influences of environment factors on the indigo naturalis quality are reduced, and the traditional Chinese medicine indigo naturalis can be effectively stored.

Description

technical field [0001] The invention belongs to the field of storage of traditional Chinese medicinal materials, and in particular relates to an effective storage method of the traditional Chinese medicinal material Qingdai. Background technique [0002] Indigo Daisy is the dry powder or pellet obtained by processing the leaves or stems of Baphicacanthus cusia (Nees) Bremek., Polygonum tinctorium Ait. or Isatis indigotica Fort. lumps or granules. [0003] Modern research shows that the organic components in Qingdai are mainly indigo, indirubin, isoindigo, tryptanthrin, isatin, sterols, pentacyclic triterpenes, anthraquinones and amino acids, etc., and the inorganic components are mainly CaCO 3 ,, SiO 2 、H 2 O and trace amounts of heavy metal elements, etc. Indigo has multiple pharmacological effects such as clearing away heat and reducing inflammation, antibacterial, antitumor and inhibiting leukemia cells, and is widely used in clinical practice. In addition, indigo is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B65D81/20B65D81/24B65D81/30
CPCB65D81/2069B65D81/24B65D81/30
Inventor 马鸿雁马倩邓玉娇车静张定堃万丽
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE