Medicinal preparation
A preparation and medicine technology, applied in the field of pharmaceutical preparations, can solve the problem of no record of stability, and achieve the effect of improving stability
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[0223] Below, the present invention is further described by enumerating examples, but the present invention is not limited by them.
[0224] In addition, in the following test examples, in the measurement of netadil using HPLC, an ODS column was used as a column, 0.01 mol / L phosphate buffer and acetonitrile were used as a mobile phase, and an ultraviolet absorptiometry (wavelength : 254nm).
manufacture example 1~36
[0300] Aqueous compositions containing the ingredients and amounts (amount (g) per 100 mL of the aqueous composition) described in Tables 9 to 17 were prepared in accordance with a conventional method, and contained in Test Example 3 using a mixture containing benzotriazole The container (primary package) for eye drops made of polypropylene, which is an ultraviolet absorber, can produce the pharmaceutical preparations of Production Examples 1 to 36.
[0301] [Table 9]
[0302]
[0303] [Table 10]
[0304]
[0305] [Table 11]
[0306]
[0307] [Table 12]
[0308]
[0309] [Table 13]
[0310]
[0311] [Table 14]
[0312]
[0313] [Table 15]
[0314]
[0315] [Table 16]
[0316]
[0317] [Table 17]
[0318]
manufacture example 37~72
[0320] In Production Examples 1 to 36, except that the container was made of polyethylene instead of polypropylene, the pharmaceutical preparations of Production Examples 37 to 72 could be produced using the same container as that used in Test Example 3.
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