3-substituted-1,5-benzodiazepine compound and pharmaceutical application thereof
Patent Information
- Authority / Receiving Office
- CN · China
- Current Assignee / Owner
- FUDAN UNIV
- Publication Date
- 2019-11-05
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Abstract
Description
technical field
[0001] The invention belongs to the technical field of medicine and relates to a new class of 3-substituted-1,5-benzazepines with the structure of formula I Ketones and their applications in medicine. The 3-substituted benzazepine The compounds can selectively inhibit the activity of glycogen synthesis kinase-3β (GSK 3β), and can be used for the preparation of drugs for the prevention and / or treatment of diseases with abnormal pathological characteristics of GSK 3β, and the diseases include cancer, neurological diseases, metabolic syndrome etc. Background technique
[0002] The prior art discloses that glycogen synthase kinase-3β (Glycogen synthase kinase-3β, GSK-3β) is a multifunctional serine / threonine protein kinase, which can phosphorylate and inactivate glycogen synthase. Studies have shown that GSK-3β can phosphorylate a variety of substrate proteins, participate in multiple important signal transduction pathways in vivo, including insulin signalin...