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Composition for preventing and treating osteoarthritis and preparation method and application of composition

A technique for osteoarthritis and composition, which is applied in the field of composition for prevention and treatment of osteoarthritis, and can solve problems such as adverse reactions, renal function damage, and obvious side effects

Inactive Publication Date: 2019-11-08
澳汀斯(广州)生物医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Non-steroidal drugs such as ibuprofen, diclofenac, meloxicam, nebumetone, etc. are the most commonly used clinically, but their side effects are also relatively obvious, such as gastrointestinal adverse reactions, renal function damage, etc.

Method used

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  • Composition for preventing and treating osteoarthritis and preparation method and application of composition
  • Composition for preventing and treating osteoarthritis and preparation method and application of composition
  • Composition for preventing and treating osteoarthritis and preparation method and application of composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The composition that is used to prevent and treat osteoarthritis of the present embodiment, every 1000g composition (preparation 1000 soft capsules) comprises the component and content as follows:

[0027] Vitamin D 3 0.01g;

[0028] Vitamin K 2 0.025g;

[0029] Fish oil 500g.

[0030] Each softgel contains 10μg of vitamin D 3 , 25 μg of vitamin K 2 (menadione-7) and 500mg of fish oil.

Embodiment 2

[0032] The composition that is used to prevent and treat osteoarthritis of the present embodiment, every 1000g composition (preparation 1000 soft capsules) comprises the component and content as follows:

[0033] Vitamin D 3 0.02g;

[0034] Vitamin K 2 0.050g;

[0035] Fish oil 750g.

[0036] Each softgel contains 20μg of vitamin D 3 , 50μg vitamin K 2 (menadione-4 and menadione-7) and 750mg of fish oil.

Embodiment 3

[0038] The composition that is used to prevent and treat osteoarthritis of the present embodiment, every 1000g composition (preparation 1000 soft capsules) comprises the component and content as follows:

[0039] Vitamin D 3 0.03g;

[0040] Vitamin K 2 0.075g;

[0041] Fish oil 1000g.

[0042] Each softgel contains 30μg of vitamin D 3 , 75μg vitamin K 2 (menadione-4) and 1000mg of fish oil.

[0043] The above-mentioned examples 1-3 are prepared by the following method: in a clean work room, the operation is protected from light, and the vitamin D 3 and vitamin K 2 Add it into fish oil, heat and stir at 40°C to dissolve to obtain the composition.

[0044]The above composition for preventing and treating osteoarthritis can be applied to medicine or food for preventing and treating osteoarthritis. When preparing the medicine, a mold is used to make soft capsules containing 1 g of the above composition, and the soft capsules are taken orally twice a day.

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Abstract

The invention provides a composition for preventing and treating osteoarthritis. The components and contents included in each 1000 g of the composition are as follows: 0.01-0.03g of vitamin D3, 0.025-0.075g of vitamin K2 and 500-1000g of fish oil. The invention further provides a preparation method of the composition and the application of the composition in medicines or food for preventing and treating arthritis. Both the vitamin D3 and the vitamin K2 are fat-soluble, and the fish oil can be used as a carrier for the vitamin D3 and the vitamin K2. The vitamin D3, the vitamin K2 and the fish oil have different protective mechanisms against the osteoarthritis. It is suggested that the combined use of the vitamin D3, the vitamin K2 and the fish oil has synergistic protective effect on the osteoarthritis.

Description

technical field [0001] The invention relates to the field of health care medicines, in particular to a composition for preventing and treating osteoarthritis, a preparation method and application thereof. Background technique [0002] Osteoarthritis is the most common form of arthritis, most commonly affecting the knee joint. It can cause pain and disability, seriously affecting people's ability to work and quality of life. According to the World Health Organization, the global prevalence of symptomatic osteoarthritis in people over 60 years old is 9.6% for men and 18% for women. In 2010, there were approximately 251 million knee osteoarthritis patients worldwide, accounting for 3.6% of the total population. Due to the increase in the average human life expectancy and the increase in obesity, the incidence of osteoarthritis will further increase. The economic burden of osteoarthritis is huge, and its cost accounts for about 1-2.5% of the gross national product of develope...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/60A61P19/02A61P29/00A23L33/155A61K31/593A61K31/122
CPCA23L33/155A23V2002/00A61K31/122A61K31/593A61K35/60A61P19/02A61P29/00A61K2300/00A23V2200/306A23V2250/7106A23V2250/7144A23V2250/7142A23V2250/7104
Inventor 丁长海朱兆华韩卫雨阮光峰
Owner 澳汀斯(广州)生物医药科技有限公司